Research workbench
Crystal structure of SARS-cov-2 NSP3 macrodomain at pH 5 (P43 crystal form)
Analyse Crystal structure of SARS-cov-2 NSP3 macrodomain at pH 5 (P43 crystal form) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TWN
- Type
- protein
- Length
- 335 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural protein 3
- EC
- 3.4.19.121, 3.4.22.-
- UniProt
- P0DTD1
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Non-structural protein 3 (EC 3.4.19.121, 3.4.22.-) | protein | 167 | 41% helix, 19% strand | P0DTD1 |
| B | Non-structural protein 3 (EC 3.4.19.121, 3.4.22.-) | protein | 168 | 42% helix, 19% strand | P0DTD1 |
Ligands and binding sites
- CIT · Citric acid · additive · 2 copies · chains A, B
- NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 455 | 0.64 | 0.77 | 35 | empty |
| 2 | 187 | 0.51 | 0.77 | 31 | CIT, NHE |
| 3 | 153 | 0.50 | 0.78 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 493 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 7TWN · Crystal structure of SARS-CoV-2 NSP3 macrodomain at pH 5 (P43 crystal form) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTD1
- Elsewhere: RCSB PDB 7TWN · PDBe 7TWN · UniProt P0DTD1
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