Research workbench
Human potassium-chloride cotransporter 1 in inward-open state
Analyse Human potassium-chloride cotransporter 1 in inward-open state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TTH
- Type
- protein
- Length
- 1,750 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Solute carrier family 12 member 4
- UniProt
- Q9UP95
- Ligands
- NAG, K
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 1 distinct chain · 52% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Solute carrier family 12 member 4 | protein | 875 | 52% helix, 8% strand | Q9UP95 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- K · Potassium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 671 | 0.78 | 0.83 | 82 | empty |
| 2 | 914 | 0.78 | 0.81 | 98 | empty |
| 3 | 601 | 0.77 | 0.83 | 78 | K |
| 4 | 767 | 0.74 | 0.79 | 59 | empty |
| 5 | 535 | 0.67 | 0.78 | 49 | empty |
Interfaces
1 interface between chains.
- A–B · 2802 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 7TTH · Human potassium-chloride cotransporter 1 in inward-open state · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UP95 · AlphaFold monomer V2.0 prediction for solute carrier family 12 member 4 (Q9UP95) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UP95
- Elsewhere: RCSB PDB 7TTH · PDBe 7TTH · UniProt Q9UP95
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