UniProt Q9UP95
Solute carrier family 12 member 4 (Q9UP95)
Solute carrier family 12 member 4 (UniProt Q9UP95): 12 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UP95
- Protein
- Solute carrier family 12 member 4
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 14 · 1 record with a druggable one
Structures
13 records of Q9UP95 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6KKR | human KCC1 structure determined in KCl and detergent GDN | electron microscopy | A, B | NAG, GLC, BGC, CL, K, DU0 | — |
| 6KKR | Human KCC1 structure determined in kcl and detergent gdn | electron microscopy | A, B | NAG, GLC, BGC, CL, K, DU0 | — |
| 6KKT | human KCC1 structure determined in KCl and lipid nanodisc | electron microscopy | A, B | NAG, GLC, BGC, CL, K, DU0 | — |
| 6KKT | Human KCC1 structure determined in kcl and lipid nanodisc | electron microscopy | A, B | NAG, GLC, BGC, CL, K, DU0 | — |
| 6KKU | human KCC1 structure determined in NaCl and GDN | electron microscopy | A, B | NAG, GLC, BGC, CL, DU0 | — |
| 6KKU | Human KCC1 structure determined in nacl and gdn | electron microscopy | A, B | NAG, GLC, BGC, CL, DU0 | — |
| 7AIP | Structure of human potassium chloride transporter KCC1 in nacl (reference MAP) | electron microscopy | A, B | NAG, ATP, MG | — |
| 7AIQ | Structure of human potassium chloride transporter KCC1 in nacl (subclass 1) | electron microscopy | A, B | NAG, ATP | — |
| 7AIR | Structure of human potassium chloride transporter KCC1 in nacl (subclass 2) | electron microscopy | A, B | NAG, ATP | — |
| 7TTH | Human potassium-chloride cotransporter 1 in inward-open state | electron microscopy | A, B | NAG, K | — |
| 7TTI | Human KCC1 bound with VU0463271 In an outward-open state | electron microscopy | A, B | NAG | — |
| 7TTI | Human KCC1 bound with VU0463271 in an outward-open state | electron microscopy | A, B | NAG | — |
| Q9UP95 | AlphaFold monomer V2.0 prediction for solute carrier family 12 member 4 (Q9UP95) | predicted | A | — | 14 (best 0.76) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 12 records
- BGC · beta-D-glucopyranose · in 6 records
- CL · Chloride ion · in 6 records
- DU0 · 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R}, 9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4, 8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol · in 6 records
- GLC · alpha-D-glucopyranose · in 6 records
- K · Potassium ion · in 5 records
- ATP · Adenosine-5'-triphosphate · in 3 records
- MG · Magnesium ion · in 1 record
Experiment against prediction
- 6KKR chain A against the predicted model Q9UP95: TM-score 0.98, RMSD 1.24 Å
- 6KKR chain A against the predicted model Q9UP95: TM-score 0.98, RMSD 1.24 Å
- 6KKT chain A against the predicted model Q9UP95: TM-score 0.98, RMSD 1.22 Å
- 6KKT chain A against the predicted model Q9UP95: TM-score 0.98, RMSD 1.22 Å
- 6KKU chain A against the predicted model Q9UP95: TM-score 0.98, RMSD 1.34 Å
- 6KKU chain A against the predicted model Q9UP95: TM-score 0.98, RMSD 1.34 Å
- 7AIR chain B against the predicted model Q9UP95: TM-score 0.97, RMSD 1.91 Å
- 7AIQ chain A against the predicted model Q9UP95: TM-score 0.96, RMSD 1.98 Å
- 7AIP chain A against the predicted model Q9UP95: TM-score 0.96, RMSD 2.20 Å
- 7AIQ chain B against the predicted model Q9UP95: TM-score 0.95, RMSD 2.21 Å
Elsewhere
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