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Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-YL)PROPYL)- 4-methylpyridin-2-amine

Analyse Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7TS2
Type: protein
Length: 1,665 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P29475
Ligands: HEM, H4B, K8F, ZN

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	420	—	P29475
B	—	protein	414	—	P29475
C	—	protein	413	—	P29475
D	—	protein	418	—	P29475

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · 4 copies · chains A, B, C, D
H4B · 5,6,7,8-tetrahydrobiopterin · ligand · 4 copies · chains A, B, C, D
K8F · 6-[3-(3,3-difluoroazetidin-1-yl)propyl]-4-methylpyridin-2-amine · ligand · 4 copies · chains A, B, C, D
ZN · Zinc ion · metal · 2 copies · chains A, B, C, D
GOL · Glycerol · additive · 6 copies · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7TS2 · Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in… · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt P29475
Elsewhere: RCSB PDB 7TS2 · PDBe 7TS2 · UniProt P29475

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