UniProt P29475
Nitric oxide synthase, brain (P29475)
Nitric oxide synthase, brain (UniProt P29475), EC 1.14.13.39: 119 experimental structures on GenesisL1, 83 ligands bound, 110 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P29475
- Protein
- Nitric oxide synthase, brain
- EC
- 1.14.13.39
- Experimental structures
- 119
- Predicted models
- 0
- Ligands
- 83
- Pockets
- 110 · 10 records with a druggable one
Structures
119 records of P29475 in the MolNFT archive: 119 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4D1N | Structure of human nNOS heme domain with L-Arg bound | x-ray diffraction | A, B, C, D | — | — |
| 4D1N | Structure of human nnos heme domain with L-arg bound | x-ray diffraction | A, B, C, D | — | — |
| 4UCH | Structure of human nNOS R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 4UCH | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 4UH5 | Structure of human nNOS R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 4UH5 | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 4UH6 | Structure of human nNOS R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 4UH6 | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 4V3U | Structure of human nNOS R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B, C, D | — | — |
| 4V3U | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B, C, D | — | — |
| 5ADF | Structure of human nNOS R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 2SN, ZN | 13 (best 0.88) |
| 5ADF | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 5ADG | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 5ADI | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 5FVU | Structure of human nNOS R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, W64, ZN | — |
| 5FVU | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 5FVV | Structure of human nNOS R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, H65, ZN | — |
| 5FVV | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 5FVW | Structure of human nNOS R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, W66, ZN | — |
| 5FVW | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 5FVX | Structure of human nNOS R354A G357D mutant heme domain in complex with with… | x-ray diffraction | A, B | HEM, H4B, W67, ZN | — |
| 5FVX | Structure of human nnos R354A G357D mutant heme domain in complex with… | x-ray diffraction | A, B | — | — |
| 5UO1 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 8EV, ZN | — |
| 5UO1 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 8EV, ZN | — |
| 5UO2 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 8J4, ZN | — |
| 5UO3 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 8EY, ZN | — |
| 5UO4 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 8F1, ZN | — |
| 5UO4 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 8F1, ZN | — |
| 5UO5 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, M4R, 8FD, ZN | — |
| 5UO6 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, M4R, ZN | — |
| 5UO6 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, M4R, ZN | — |
| 5UO7 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 8FD, ZN | — |
| 5UO7 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 8FD, ZN | — |
| 5VUV | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, M62, ZN | — |
| 5VUW | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, JHT, ZN | — |
| 5VUX | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 9P1, ZN | 10 (best 0.86) |
| 5VUX | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 9P1, ZN | — |
| 5VUY | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, P64, ZN | — |
| 5VUZ | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, XH8, ZN | 10 (best 0.88) |
| 5VUZ | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, XH8, ZN | — |
| 5VV0 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 9OM, ZN | — |
| 5VV1 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 9OS, ZN | — |
| 5VV2 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 9P4, ZN | — |
| 5VV3 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, P94, ZN | — |
| 5VV3 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, P94, ZN | — |
| 5VV4 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 9P7, ZN | — |
| 5VV5 | Structure of human neuronal nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 9OJ, ZN | — |
| 6AUY | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, ZN, BYJ | — |
| 6AUZ | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, W68, ZN | — |
| 6AV0 | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, ZN, BYV | — |
| 6AV0 | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, ZN, BYV | — |
| 6AV1 | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, W69, ZN | — |
| 6AV1 | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, W69, ZN | — |
| 6AV2 | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, BY7, ZN | — |
| 6AV2 | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, BY7, ZN | — |
| 6AV3 | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, W79, ZN | — |
| 6AV4 | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, W80, ZN | — |
| 6AV5 | Structure of human neuronal nitric oxide synthase R354A/G356D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, W82, ZN | — |
| 6CIC | Structure of the human nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, 7R2, ZN | — |
| 6CID | Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with… | x-ray diffraction | A, B | HEM, H4B, F2J, ZN | — |
59 records more on the page itself.
Ligands
- HEM · Protoporphyrin IX containing Fe · in 100 records
- ZN · Zinc ion · in 100 records
- H4B · 5,6,7,8-tetrahydrobiopterin · in 96 records
- 8FD · 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2S)-2-(methylamino)propyl]benzonitrile · in 3 records
- M4R · 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2R)-2-(methylamino)propyl]benzonitrile · in 3 records
- 8EV · 3-[(2-aminoquinolin-7-yl)methoxy]-5-[(methylamino)methyl]benzonitrile · in 2 records
- 8F1 · 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[2-(methylamino)ethyl]benzonitrile · in 2 records
- 9P1 · 7-[({[4-(dimethylamino)phenyl]methyl}amino) methyl]quinolin-2-amine · in 2 records
- BY7 · 6-(2-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl) phenyl}ethyl)-4-methylpyridin-2-amine · in 2 records
- BYV · 3-[2-(6-amino-4-methylpyridin-2-yl)ethyl]-5-[3-(methylamino)propyl]benzonitrile · in 2 records
- KMA · 6-[2-(3-fluoro-5-{2-[(2R)-pyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine · in 2 records
- KMS · 6-(2-{5-[3-(dimethylamino)propyl]-2,3,4-trifluorophenyl}ethyl)-4-methylpyridin-2-amine · in 2 records
- KPJ · 6-[2-(2,3-difluoro-5-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}phenyl)ethyl]-4-methylpyridin-2-amine · in 2 records
- OSD · 7-{3-(aminomethyl)-4-[(propan-2-yl)oxy]phenyl}-4-methylquinolin-2-amine · in 2 records
- OSY · 7-[4-(aminomethyl)phenyl]-4-methylquinolin-2-amine · in 2 records
- OT4 · 7-[3-(2-aminoethyl)phenyl]-4-methylquinolin-2-amine · in 2 records
- OU7 · 7-{3-(aminomethyl)-4-[(1,3-thiazol-5-yl) methoxy]phenyl}-4-methylquinolin-2-amine · in 2 records
- OUG · 7-[3-(aminomethyl)phenyl]-4-methylquinolin-2-amine · in 2 records
- OUM · 4-{[2-(aminomethyl)-4-(2-amino-4-methylquinolin-7-yl) phenoxy]methyl}benzonitrile · in 2 records
- P94 · 4-(2-{[(2-aminoquinolin-7-yl)methyl]amino}ethyl) benzonitrile · in 2 records
- W69 · 6-(2-{3-[3-(dimethylamino)propyl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine · in 2 records
- XH8 · 7-(((3-(pyridin-3-yl)propyl)amino)methyl)quinolin-2- · in 2 records
- 2SN · 7-[[[3-[(dimethylamino)methyl]phenyl]amino]methyl]quinolin-2-amine · in 1 record
- 7R2 · N-(1-{2-[ethyl(methyl)amino]ethyl}-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide · in 1 record
- 8EY · 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(methylamino)methyl]benzonitrile · in 1 record
- 8J4 · 7-({3-ethyl-5-[(methylamino)methyl]phenoxy}methyl) quinolin-2-amine · in 1 record
- 9OJ · 4-(2-{[(2-amino-4-methylquinolin-7-yl) methyl]amino}ethyl)-2-methylbenzonitrile · in 1 record
- 9OM · 7-({[3-(4-methylpyridin-3-yl)propyl]amino}methyl) quinolin-2-amine · in 1 record
- 9OS · 7-({[3-(4-methoxypyridin-3-yl)propyl]amino}methyl) quinolin-2-amine · in 1 record
- 9P4 · 7-({[3-(5-fluoropyridin-3-yl)propyl]amino}methyl) quinolin-2-amine · in 1 record
Elsewhere
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