Research workbench
Crystal structure of the human SNX25 regulator of G-protein signalling (rgs) domain
Analyse Crystal structure of the human SNX25 regulator of G-protein signalling (rgs)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7SR2
- Type
- protein
- Length
- 233 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sorting nexin-25
- UniProt
- A0A494C0S0
- Ligands
- LEU, ZN
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sorting nexin-25 | protein | 116 | 68% helix, 0% strand | A0A494C0S0 |
| B | Sorting nexin-25 | protein | 117 | 74% helix, 0% strand | A0A494C0S0 |
Ligands and binding sites
- LEU · Leucine · ligand · chains B
- ZN · Zinc ion · metal · chains A, B
- ACT · Acetate ion · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 422 | 0.61 | 0.76 | 34 | empty |
| 2 | 185 | 0.46 | 0.75 | 23 | ACT |
| 3 | 80 | 0.32 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 468 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7SR2 · Crystal structure of the human SNX25 regulator of G-protein signalling (RGS) domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A494C0S0
- Elsewhere: RCSB PDB 7SR2 · PDBe 7SR2 · UniProt A0A494C0S0
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