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Structure of G6PD-wt dimer

Analyse Structure of G6PD-wt dimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7SNF
Type: protein
Length: 938 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucose-6-phosphate 1-dehydrogenase
EC: 1.1.1.49
UniProt: P11413
Pockets: 11 · best druggability 0.69

Structure

electron microscopy · 1 distinct chain · 35% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	protein	469	35% helix, 18% strand	P11413

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	522	0.69	0.79	47	empty
2	505	0.68	0.79	43	empty
3	87	0.59	0.88	18	empty
4	67	0.56	0.88	19	empty
5	81	0.44	0.80	15	empty

Interfaces

1 interface between chains.

A–B · 2225 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

7SNF · Structure of G6PD-WT dimer · the same entry in another collection · chain A against A, TM-score 1.00
P11413 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate 1-dehydrogenase (P11413) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11413
Elsewhere: RCSB PDB 7SNF · PDBe 7SNF · UniProt P11413

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