UniProt P11413
Glucose-6-phosphate 1-dehydrogenase (P11413)
Glucose-6-phosphate 1-dehydrogenase (UniProt P11413), EC 1.1.1.49: 38 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 160 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P11413
- Protein
- Glucose-6-phosphate 1-dehydrogenase
- EC
- 1.1.1.49
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 160 · 14 records with a druggable one
Structures
39 records of P11413 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1QKI | X-ray structure of human glucose 6-phosphate dehydrogenase (variant canton R459L) complexed with… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1QKI | X-ray structure of human glucose 6-phosphate dehydrogenase (variant canton R459L) complexed with… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2BH9 | X-ray structure of a deletion variant of human glucose 6-phosphate dehydrogenase complexed with… | x-ray diffraction | A | — | — |
| 2BH9 | X-ray structure of a deletion variant of human glucose 6-phosphate dehydrogenase complexed with… | x-ray diffraction | A | — | — |
| 2BHL | X-ray structure of human glucose-6-phosphate dehydrogenase (deletion variant) complexed with… | x-ray diffraction | A, B | — | — |
| 2BHL | X-ray structure of human glucose-6-phosphate dehydrogenase (deletion variant) complexed with… | x-ray diffraction | A, B | — | — |
| 5UKW | Crystal structure of human Glucose 6-phosphate Dehydrogenase mutant (A277C) complexed with G6P | x-ray diffraction | A | BG6 | 4 (best 0.68) |
| 5UKW | Crystal structure of human glucose 6-phosphate dehydrogenase mutant (A277C) complexed with G6P | x-ray diffraction | A | BG6 | — |
| 6E07 | Crystal structure of Canton G6PD in complex with structural NADP | x-ray diffraction | L, C, F, N, Q, T, W, B | NAP, PO4 | 20 (best 0.87) |
| 6E07 | Crystal structure of canton G6PD in complex with structural NADP | x-ray diffraction | L, C, F, N, Q, T, W, B | NAP, PO4 | — |
| 6E08 | Crystal structure of G6PD in complex with structural NADP | x-ray diffraction | L | NAP | 4 (best 0.65) |
| 6E08 | Crystal structure of G6PD in complex with structural NADP | x-ray diffraction | L | NAP | — |
| 6JYU | Crystal structure of Human G6PD Canton | x-ray diffraction | A | NAP | — |
| 6JYU | Crystal structure of human G6PD canton | x-ray diffraction | A | NAP | — |
| 6VA0 | Crystal structure of glucose-6-phosphate dehydrogenase W509A mutant in complex with catalytic NADP+ | x-ray diffraction | A | NAP | 5 (best 0.72) |
| 6VA0 | Crystal structure of glucose-6-phosphate dehydrogenase W509A mutant in complex with catalytic NADP+ | x-ray diffraction | A | NAP | — |
| 6VA7 | Crystal structure of glucose-6-phosphate dehydrogenase P396L mutant in complex with catalytic NADP+ | x-ray diffraction | A | NAP | — |
| 6VA7 | Crystal structure of glucose-6-phosphate dehydrogenase P396L mutant in complex with catalytic NADP+ | x-ray diffraction | A | NAP | — |
| 6VA8 | Crystal structure of glucose-6-phosphate dehydrogenase F381L mutant in complex with catalytic NADP+ | x-ray diffraction | A | NAP | 3 (best 0.76) |
| 6VA8 | Crystal structure of glucose-6-phosphate dehydrogenase F381L mutant in complex with catalytic NADP+ | x-ray diffraction | A | NAP | — |
| 6VA9 | Crystal structure of glucose-6-phosphate dehydrogenase R393H mutant in complex with catalytic NADP+ | x-ray diffraction | A | NAP | — |
| 6VA9 | Crystal structure of glucose-6-phosphate dehydrogenase R393H mutant in complex with catalytic NADP+ | x-ray diffraction | A | NAP | — |
| 6VAQ | Crystal structure of glucose-6-phosphate dehydrogenase V394L mutant in complex with catalytic NADP+ | x-ray diffraction | A | NAP | 5 (best 0.72) |
| 6VAQ | Crystal structure of glucose-6-phosphate dehydrogenase V394L mutant in complex with catalytic NADP+ | x-ray diffraction | A | NAP | — |
| 7SEH | Glucose-6-phosphate 1-dehydrogenase (K403QdLtL) | x-ray diffraction | A, B | NAP | 6 (best 0.82) |
| 7SEH | Glucose-6-phosphate 1-dehydrogenase (K403QDLTL) | x-ray diffraction | A, B | NAP | — |
| 7SEI | Glucose-6-phosphate 1-dehydrogenase (K403Q) | x-ray diffraction | A | NAP | — |
| 7SNF | Structure of G6PD-WT dimer | electron microscopy | A, B | — | 11 (best 0.69) |
| 7SNF | Structure of G6PD-wt dimer | electron microscopy | A, B | — | — |
| 7SNG | structure of G6PD-WT tetramer | electron microscopy | A, B, C, D | — | 20 (best 0.87) |
| 7SNG | Structure of G6PD-wt tetramer | electron microscopy | A, B, C, D | — | — |
| 7SNH | Structure of G6PD-D200N tetramer bound to NADP+ | electron microscopy | A, B, C, D | NAP | — |
| 7SNI | Structure of G6PD-D200N tetramer bound to NADP+ and G6P | electron microscopy | A, B, C, D | NAP, BG6 | 20 (best 0.87) |
| 7SNI | Structure of G6PD-D200N tetramer bound to NADP+ and G6P | electron microscopy | A, B, C, D | NAP, BG6 | — |
| 7TOF | Structure of G6PD-WT dimer with no symmetry applied | electron microscopy | A, B | — | 11 (best 0.74) |
| 7UAG | Structure of G6PD-WT dimer | electron microscopy | A, B | — | 11 (best 0.69) |
| 7UAL | Structure of G6PD-D200N tetramer bound to NADP+ and G6P with no symmetry applied | electron microscopy | A, B, C, D | NAP, BG6 | 20 (best 0.87) |
| 7ZVE | K403 acetylated glucose-6-phosphate dehydrogenase (G6PD) | x-ray diffraction | A, B, C, D, E, F, G, H | CU | 20 (best 0.73) |
| P11413 | AlphaFold monomer V2.0 prediction for glucose-6-phosphate 1-dehydrogenase (P11413) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6JYU chain A against the predicted model P11413: TM-score 1.00, RMSD 0.40 Å
- 6JYU chain A against the predicted model P11413: TM-score 1.00, RMSD 0.40 Å
- 6E07 chain L against the predicted model P11413: TM-score 1.00, RMSD 0.40 Å
- 6E07 chain L against the predicted model P11413: TM-score 1.00, RMSD 0.40 Å
- 6E08 chain L against the predicted model P11413: TM-score 1.00, RMSD 0.41 Å
- 6E08 chain L against the predicted model P11413: TM-score 1.00, RMSD 0.41 Å
- 5UKW chain A against the predicted model P11413: TM-score 1.00, RMSD 0.42 Å
- 5UKW chain A against the predicted model P11413: TM-score 1.00, RMSD 0.42 Å
- 6E07 chain C against the predicted model P11413: TM-score 1.00, RMSD 0.54 Å
- 6E07 chain C against the predicted model P11413: TM-score 1.00, RMSD 0.54 Å
Elsewhere
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