Research workbench

Cryoem structure of SGLT1 at 3.4 a resolution

Analyse Cryoem structure of SGLT1 at 3.4 a resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7SL8
Type: protein
Length: 700 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SODIUM/GLUCOSE cotransporter 1; Nanobody NB1
Ligands: CLR
Pockets: 7 · best druggability 0.72

Structure

electron microscopy · 2 distinct chains · 56% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SODIUM/GLUCOSE cotransporter 1	protein	582	67% helix, 2% strand	—
B	Nanobody NB1	protein	118	0% helix, 38% strand	—

Ligands and binding sites

CLR · Cholesterol · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.72	0.97	18	empty
2	567	0.68	0.78	57	empty
3	266	0.62	0.81	43	empty
4	91	0.51	0.82	18	empty
5	66	0.43	0.81	21	empty

Interfaces

1 interface between chains.

A–B · 737 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

7SL8 · CryoEM structure of SGLT1 at 3.4 A resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7SL8 · PDBe 7SL8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.