Research workbench
Cryo-EM structure of the rt component of the HIV-1 pol polyprotein
Analyse Cryo-EM structure of the rt component of the HIV-1 pol polyprotein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7SEP
- Type
- protein
- Length
- 930 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gag-pol polyprotein
- UniProt
- P03366
- Pockets
- 17 · best druggability 0.74
Structure
electron microscopy · 2 distinct chains · 34% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gag-pol polyprotein | protein | 532 | 32% helix, 18% strand | P03366 |
| B | Gag-pol polyprotein | protein | 398 | 36% helix, 18% strand | P03366 |
Pockets
17 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 568 | 0.74 | 0.81 | 78 | empty |
| 2 | 624 | 0.74 | 0.81 | 36 | empty |
| 3 | 176 | 0.73 | 0.90 | 31 | empty |
| 4 | 593 | 0.71 | 0.79 | 48 | empty |
| 5 | 520 | 0.68 | 0.78 | 55 | empty |
Interfaces
1 interface between chains.
- A–B · 2557 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 7SEP · Cryo-EM Structure of the RT component of the HIV-1 Pol Polyprotein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03366
- Elsewhere: RCSB PDB 7SEP · PDBe 7SEP · UniProt P03366
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