Research workbench
MRG15 complex with PALB2 peptide
Analyse MRG15 complex with PALB2 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7S4A
- Type
- protein
- Length
- 386 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mortality factor 4-like protein 1; Partner and localizer of BRCA2
- UniProt
- Q9UBU8, Q86YC2
- Pockets
- 4 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 65% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mortality factor 4-like protein 1 | protein | 159 | 65% helix, 5% strand | Q9UBU8 |
| B | Partner and localizer of BRCA2 | protein | 32 | 59% helix, 0% strand | Q86YC2 |
| C | Mortality factor 4-like protein 1 | protein | 160 | 65% helix, 4% strand | Q9UBU8 |
| D | Partner and localizer of BRCA2 | protein | 35 | 66% helix, 0% strand | Q86YC2 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 748 | 0.76 | 0.81 | 68 | empty |
| 2 | 175 | 0.59 | 0.82 | 28 | empty |
| 3 | 176 | 0.50 | 0.76 | 20 | empty |
| 4 | 109 | 0.44 | 0.77 | 18 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1197 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1148 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 553 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 258 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 210 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7S4A · MRG15 complex with PALB2 peptide · the same entry in another collection · chain D against D, TM-score 1.00
- Q9UBU8 · AlphaFold monomer V2.0 prediction for mortality factor 4-like protein 1 (Q9UBU8) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q86YC2 · AlphaFold monomer V2.0 prediction for partner and localizer of BRCA2 (Q86YC2) · a predicted model of the same protein · chain D against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBU8
- Every structure of UniProt Q86YC2
- Elsewhere: RCSB PDB 7S4A · PDBe 7S4A · UniProt Q9UBU8 · UniProt Q86YC2
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