Research workbench
Insulin degrading enzyme O/O
Analyse Insulin degrading enzyme O/O in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RZH
- Type
- protein
- Length
- 1,867 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine-free insulin-degrading enzyme
- EC
- 3.4.24.56
- UniProt
- P14735
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 2 distinct chains · 45% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine-free insulin-degrading enzyme (EC 3.4.24.56) | protein | 932 | 46% helix, 17% strand | P14735 |
| B | Cysteine-free insulin-degrading enzyme (EC 3.4.24.56) | protein | 935 | 44% helix, 16% strand | P14735 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 575 | 0.87 | 0.92 | 55 | empty |
| 2 | 988 | 0.77 | 0.79 | 83 | empty |
| 3 | 630 | 0.76 | 0.82 | 68 | empty |
| 4 | 99 | 0.75 | 0.95 | 28 | empty |
| 5 | 1176 | 0.74 | 0.77 | 118 | empty |
Interfaces
1 interface between chains.
- A–B · 1446 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7RZH · Insulin Degrading Enzyme O/O · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14735
- Elsewhere: RCSB PDB 7RZH · PDBe 7RZH · UniProt P14735
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