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Alternate crystal form of human malate dehydrogenase I
Analyse Alternate crystal form of human malate dehydrogenase I in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RRL
- Type
- protein
- Length
- 655 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Malate dehydrogenase, cytoplasmic
- EC
- 1.1.1.37, 1.1.1.96
- UniProt
- P40925
- Pockets
- 7 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37, 1.1.1.96) | protein | 327 | 45% helix, 19% strand | P40925 |
| B | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37, 1.1.1.96) | protein | 328 | 45% helix, 20% strand | P40925 |
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.67 | 0.96 | 16 | empty |
| 2 | 529 | 0.66 | 0.77 | 54 | empty |
| 3 | 375 | 0.58 | 0.76 | 53 | empty |
| 4 | 390 | 0.57 | 0.74 | 63 | empty |
| 5 | 139 | 0.52 | 0.80 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1803 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40925
- Elsewhere: RCSB PDB 7RRL · PDBe 7RRL · UniProt P40925
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