Research workbench
Cryo-EM structure of nanodisc reconstituted ABCD1 in inward open conformation
Analyse Cryo-EM structure of nanodisc reconstituted ABCD1 in inward open conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RRA
- Type
- protein
- Length
- 1,204 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-binding cassette sub-family D member 1
- EC
- 7.6.2.4
- UniProt
- P33897
- Pockets
- 17 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 66% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | ATP-binding cassette sub-family D member 1 (EC 7.6.2.4) | protein | 602 | 66% helix, 8% strand | P33897 |
Pockets
17 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 980 | 0.84 | 0.85 | 130 | empty |
| 2 | 147 | 0.81 | 0.96 | 25 | empty |
| 3 | 131 | 0.78 | 0.96 | 21 | empty |
| 4 | 943 | 0.77 | 0.79 | 97 | empty |
| 5 | 251 | 0.73 | 0.87 | 40 | empty |
Interfaces
1 interface between chains.
- B–A · 5034 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 7RRA · Cryo-EM Structure of Nanodisc reconstituted ABCD1 in inward open conformation · the same entry in another collection · chain B against B, TM-score 1.00
- P33897 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family D member 1 (P33897) · a predicted model of the same protein · chain B against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33897
- Elsewhere: RCSB PDB 7RRA · PDBe 7RRA · UniProt P33897
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