Research workbench
Structure of ligand-free ALDH1L1 (10-formyltetrahydrofolate dehydrogenase)
Analyse Structure of ligand-free ALDH1L1 (10-formyltetrahydrofolate dehydrogenase) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RLT
- Type
- protein
- Length
- 2,324 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytosolic 10-formyltetrahydrofolate dehydrogenase
- EC
- 1.5.1.6
- UniProt
- P28037
- Ligands
- PNS
- Pockets
- 20 · best druggability 0.90
Structure
electron microscopy · 1 distinct chain · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, B, D | Cytosolic 10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) | protein | 581 | 43% helix, 17% strand | P28037 |
Ligands and binding sites
- PNS · 4'-phosphopantetheine · ligand · 4 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1086 | 0.90 | 0.92 | 170 | PNS |
| 2 | 1029 | 0.90 | 0.92 | 153 | PNS |
| 3 | 475 | 0.83 | 0.89 | 72 | empty |
| 4 | 259 | 0.81 | 0.93 | 30 | empty |
| 5 | 752 | 0.80 | 0.84 | 61 | empty |
Interfaces
6 interfaces between chains.
- A–C · 2804 Ų buried · 47 hydrogen bonds · protein-protein
- B–D · 2784 Ų buried · 47 hydrogen bonds · protein-protein
- C–D · 2731 Ų buried · 41 hydrogen bonds · protein-protein
- A–B · 2719 Ų buried · 42 hydrogen bonds · protein-protein
- C–B · 1607 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 cofactor (phosphopantetheinylation).
Compared structures
- 7RLT · Structure of ligand-free ALDH1L1 (10-formyltetrahydrofolate dehydrogenase) · the same entry in another collection · chain D against D, TM-score 1.00
- P28037 · AlphaFold monomer V2.0 prediction for cytosolic 10-formyltetrahydrofolate dehydrogenase… · a predicted model of the same protein · chain C against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28037
- Elsewhere: RCSB PDB 7RLT · PDBe 7RLT · UniProt P28037
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