Crystal structure of human bromodomain containing protein 3 (BRD3) in complex with BCLTF1

Structure

x-ray diffraction · 3 distinct chains · 54% helix, 0% strand (DSSP).

Ligands and binding sites

• EDO · 1,2-ethanediol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

3 interfaces between chains.

• A–B · 1049 Ų buried · 8 hydrogen bonds · protein-protein
• A–C · 443 Ų buried · 3 hydrogen bonds · protein-protein
• B–D · 441 Ų buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (acetylation).

Compared structures

• 7RJN · Crystal structure of human bromodomain containing protein 3 (BRD3) in complex with BCLTF1 · the same entry in another collection · chain D against D, TM-score 1.00
• Q15059 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 3 (Q15059) · a predicted model of the same protein · chain A against A, TM-score 0.98
• Q9NYF8 · AlphaFold monomer V2.0 prediction for BCL-2-associated transcription factor 1 (Q9NYF8) · a predicted model of the same protein · chain C against A, TM-score 0.82

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q15059
• Every structure of UniProt Q9NYF8
• Elsewhere: RCSB PDB 7RJN · PDBe 7RJN · UniProt Q15059 · UniProt Q9NYF8