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Importin ALPHA2 in complex with ORF4B bat coronavirus HKU5

Analyse Importin ALPHA2 in complex with ORF4B bat coronavirus HKU5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7RG6
Type: protein
Length: 437 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; Non-structural protein ORF4B
UniProt: P52293, A3EXD3
Pockets: 1 · best druggability 0.41

Structure

x-ray diffraction · 3 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-1	protein	425	75% helix, 0% strand	P52293
C	Non-structural protein ORF4B	protein	6	0% helix, 0% strand	A3EXD3
D	Non-structural protein ORF4B	protein	6	0% helix, 0% strand	A3EXD3

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.41	0.81	12	empty

Interfaces

2 interfaces between chains.

A–C · 669 Å² buried · 19 hydrogen bonds · protein-protein
A–D · 626 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

7RG6 · Importin alpha2 in complex with ORF4B Bat coronavirus HKU5 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Every structure of UniProt A3EXD3
Elsewhere: RCSB PDB 7RG6 · PDBe 7RG6 · UniProt P52293 · UniProt A3EXD3

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