Research workbench
Importin ALPHA2 in complex with MERS ORF4B R24A mutant
Analyse Importin ALPHA2 in complex with MERS ORF4B R24A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RG0
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; ORF4B
- UniProt
- P52293, T2BB21
- Pockets
- 1 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-1 | protein | 425 | 74% helix, 0% strand | P52293 |
| B | ORF4B | protein | 7 | 0% helix, 0% strand | T2BB21 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.41 | 0.80 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 697 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 7RG0 · Importin alpha2 in complex with MERS ORF4B R24A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt T2BB21
- Elsewhere: RCSB PDB 7RG0 · PDBe 7RG0 · UniProt P52293 · UniProt T2BB21
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