Research workbench
Importin alpha 2 in complex with MERS ORF4B nls peptide
Analyse Importin alpha 2 in complex with MERS ORF4B nls peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RFZ
- Type
- protein
- Length
- 444 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; ORF4B
- UniProt
- P52293, T2BB21
- Pockets
- 3 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-1 | protein | 425 | 74% helix, 0% strand | P52293 |
| B | ORF4B | protein | 19 | 0% helix, 0% strand | T2BB21 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.45 | 0.79 | 17 | empty |
| 2 | 65 | 0.44 | 0.82 | 12 | empty |
| 3 | 51 | 0.29 | 0.75 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 1332 Ų buried · 34 hydrogen bonds · protein-protein
Compared structures
- 7RFZ · Importin alpha 2 in complex with MERS ORF4B NLS peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt T2BB21
- Elsewhere: RCSB PDB 7RFZ · PDBe 7RFZ · UniProt P52293 · UniProt T2BB21
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