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Crystal structure of a PMS2 vus
Analyse Crystal structure of a PMS2 vus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RCB
- Type
- protein
- Length
- 599 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mismatch repair endonuclease PMS2
- EC
- 3.1.-.-
- UniProt
- P54278
- Pockets
- 7 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) | protein | 304 | 38% helix, 26% strand | P54278 |
| B | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) | protein | 295 | 39% helix, 26% strand | P54278 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 477 | 0.71 | 0.81 | 76 | empty |
| 2 | 366 | 0.62 | 0.78 | 43 | empty |
| 3 | 77 | 0.47 | 0.82 | 16 | empty |
| 4 | 80 | 0.43 | 0.80 | 15 | empty |
| 5 | 74 | 0.37 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1182 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54278
- Elsewhere: RCSB PDB 7RCB · PDBe 7RCB · UniProt P54278
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