Research workbench

Aeronamide N-methyltransferase, aere (D141A)

Analyse Aeronamide N-methyltransferase, aere (D141A) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7RC4
Type: protein
Length: 375 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methyltransferase family protein
UniProt: A0A329B7M1
Ligands: SAH, NA, CA
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methyltransferase family protein	protein	375	40% helix, 23% strand	A0A329B7M1

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · chains A
NA · Sodium ion · metal · 2 copies · chains A
CA · Calcium ion · metal · chains A
PG4 · Tetraethylene glycol · additive · chains A
P6G · Hexaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	669	0.76	0.81	78	SAH, NA
2	71	0.33	0.76	13	empty

Compared structures

7RC4 · Aeronamide N-methyltransferase, AerE (D141A) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A329B7M1
Elsewhere: RCSB PDB 7RC4 · PDBe 7RC4 · UniProt A0A329B7M1

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