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LC3A in complex with fragment 1-1

Analyse LC3A in complex with fragment 1-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7R9W
Type: protein
Length: 115 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated proteins 1A/1B light chain 3A
UniProt: Q9H492
Ligands: JO4
Pockets: 2 · best druggability 0.28

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Microtubule-associated proteins 1A/1B light chain 3A	protein	115	33% helix, 23% strand	Q9H492

Ligands and binding sites

JO4 · 4-phenoxybenzoic acid · ligand · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.28	0.74	15	empty
2	52	0.27	0.74	18	empty

Compared structures

7R9W · LC3A in complex with Fragment 1-1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9H492 · AlphaFold monomer V2.0 prediction for microtubule-associated proteins 1A/1B light chain… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H492
Elsewhere: RCSB PDB 7R9W · PDBe 7R9W · UniProt Q9H492

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