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Crystal structure of lactose permease

Analyse Crystal structure of lactose permease in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1PV6
Type: protein
Length: 834 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lactose permease
UniProt: P02920
Pockets: 7 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Lactose permease	protein	417	81% helix, 0% strand	P02920

Pockets

7 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1022	0.82	0.83	84	empty
2	1070	0.82	0.82	90	empty
3	702	0.74	0.79	79	empty
4	162	0.53	0.80	25	empty
5	81	0.53	0.85	24	empty

Interfaces

1 interface between chains.

A–B · 418 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1PV6 · Crystal structure of lactose permease · the same entry in another collection · chain A against A, TM-score 1.00
P02920 · AlphaFold monomer V2.0 prediction for lactose permease (P02920) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02920
Elsewhere: RCSB PDB 1PV6 · PDBe 1PV6 · UniProt P02920

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