Research workbench
Neurofibromin occluded conformation
Analyse Neurofibromin occluded conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7R03
- Type
- protein
- Length
- 4,487 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform I of neurofibromin
- UniProt
- P21359
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 2 distinct chains · 64% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform I of neurofibromin | protein | 2241 | 64% helix, 4% strand | P21359 |
| B | Isoform I of neurofibromin | protein | 2246 | 64% helix, 4% strand | P21359 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 478 | 0.86 | 0.91 | 36 | empty |
| 2 | 386 | 0.85 | 0.92 | 39 | empty |
| 3 | 299 | 0.83 | 0.93 | 60 | empty |
| 4 | 136 | 0.77 | 0.94 | 26 | empty |
| 5 | 470 | 0.71 | 0.81 | 61 | empty |
Interfaces
1 interface between chains.
- A–B · 4776 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 7R03 · Neurofibromin occluded conformation · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21359
- Elsewhere: RCSB PDB 7R03 · PDBe 7R03 · UniProt P21359
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