UniProt P21359
Neurofibromin (P21359)
Neurofibromin (UniProt P21359): 38 experimental structures on GenesisL1, 5 ligands bound, 184 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P21359
- Protein
- Neurofibromin
- Experimental structures
- 38
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 184 · 12 records with a druggable one
Structures
38 records of P21359 in the MolNFT archive: 38 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NF1 | The gap related domain of neurofibromin | x-ray diffraction | A | — | — |
| 1NF1 | The gap related domain of neurofibromin | x-ray diffraction | A | — | — |
| 2D4Q | Crystal structure of the Sec-PH domain of the human neurofibromatosis type 1 protein | x-ray diffraction | A, B | — | — |
| 2D4Q | Crystal structure of the sec-pH domain of the human neurofibromatosis type 1 protein | x-ray diffraction | A, B | — | — |
| 2E2X | Sec14 Homology Module of Neurofibromin in complex with phosphatitylethanolamine | x-ray diffraction | A, B | — | — |
| 2E2X | SEC14 homology module of neurofibromin in complex with phosphatitylethanolamine | x-ray diffraction | A, B | — | — |
| 3P7Z | Crystal structure of the Neurofibromin Sec14-PH module containing the patient derived mutation… | x-ray diffraction | A, B | — | — |
| 3P7Z | Crystal structure of the neurofibromin SEC14-pH module containing the patient derived mutation… | x-ray diffraction | A, B | — | — |
| 3PEG | Crystal structure of Neurofibromins Sec14-PH module containing a patient derived duplication (TD) | x-ray diffraction | A | — | — |
| 3PEG | Crystal structure of neurofibromins SEC14-pH module containing a patient derived duplication (td) | x-ray diffraction | A | — | — |
| 3PG7 | Crystal structure of the H. sapiens NF1 SEC-PH domain (del1750 mutant) | x-ray diffraction | A, B | — | — |
| 3PG7 | Crystal structure of the H. sapiens NF1 sec-pH domain (DEL1750 mutant) | x-ray diffraction | A, B | — | — |
| 6OB2 | Crystal structure of wild-type KRAS (gmppnp-bound) in complex with gap-related domain (grd) of… | x-ray diffraction | B, D | — | — |
| 6OB3 | Crystal structure of G13D-KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of… | x-ray diffraction | B, D | GNP, CL | 12 (best 0.74) |
| 6OB3 | Crystal structure of G13D-KRAS (gmppnp-bound) in complex with gap- related domain (grd) of… | x-ray diffraction | B, D | GNP, CL | — |
| 6V65 | Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex | x-ray diffraction | B | — | 6 (best 0.77) |
| 6V65 | Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex | x-ray diffraction | B | — | — |
| 6V6F | Crystal structure of Q61L KRAS(GMPPNP)-NF1(GRD)-SPRED1(EVH1) complex | x-ray diffraction | B | — | — |
| 7MOC | Neurofibromin core | electron microscopy | A, B | — | — |
| 7MP5 | Autoinhibited neurofibrobmin | electron microscopy | A, B | — | 20 (best 0.82) |
| 7MP5 | Autoinhibited neurofibrobmin | electron microscopy | A, B | — | — |
| 7MP6 | Neurofibromin homodimer | electron microscopy | A, B | — | 20 (best 0.67) |
| 7MP6 | Neurofibromin homodimer | electron microscopy | A, B | — | — |
| 7PGP | The core structure of human neurofibromin isoform 2 | electron microscopy | F, N | — | 20 (best 0.68) |
| 7PGP | The core structure of human neurofibromin isoform 2 | electron microscopy | F, N | — | — |
| 7PGR | The structure of human neurofibromin isoform 2 in closed conformation | electron microscopy | N, F | ZN | 20 (best 0.86) |
| 7PGR | The structure of human neurofibromin isoform 2 in closed conformation | electron microscopy | N, F | ZN | — |
| 7PGS | Consensus structure of human Neurofibromin isoform 2 | electron microscopy | N, F | ZN | 20 (best 0.86) |
| 7PGS | Consensus structure of human neurofibromin isoform 2 | electron microscopy | N, F | ZN | — |
| 7PGT | The structure of human neurofibromin isoform 2 in opened conformation. | electron microscopy | N, F | ZN | 20 (best 0.86) |
| 7PGT | The structure of human neurofibromin isoform 2 in opened conformation. | electron microscopy | N, F | ZN | — |
| 7PGU | Autoinhibited structure of human neurofibromin isoform 2 stabilized by Zinc. | electron microscopy | F, N | PEV, ZN | 20 (best 0.86) |
| 7PGU | Autoinhibited structure of human neurofibromin isoform 2 stabilized by zinc. | electron microscopy | F, N | PEV, ZN | — |
| 7R03 | Neurofibromin occluded conformation | electron microscopy | A, B | — | — |
| 7R04 | Neurofibromin in open conformation | electron microscopy | A, B | GSP | — |
| 8EDL | Cryo-EM structure of the full-length human NF1 dimer | electron microscopy | A | — | 8 (best 0.79) |
| 8EDM | Cryo-EM structure of the full-length human NF1 dimer | electron microscopy | A, B | — | 3 (best 0.84) |
| 8EDO | Cryo-EM structure of the full-length human NF1 dimer | electron microscopy | A, B | — | 15 (best 0.79) |
Ligands
Elsewhere
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