Research workbench
TMEM106B filaments with fold iia from multiple system atrophy (case 19)
Analyse TMEM106B filaments with fold iia from multiple system atrophy (case 19) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QWG
- Type
- protein
- Length
- 405 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transmembrane protein 106B
- UniProt
- Q9NUM4
- Pockets
- 3 · best druggability 0.53
Structure
electron microscopy · 1 distinct chain · 0% helix, 60% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Transmembrane protein 106B | protein | 135 | 0% helix, 60% strand | Q9NUM4 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 263 | 0.53 | 0.76 | 26 | empty |
| 2 | 177 | 0.51 | 0.78 | 30 | empty |
| 3 | 57 | 0.48 | 0.84 | 15 | empty |
Interfaces
3 interfaces between chains.
- B–C · 5973 Ų buried · 168 hydrogen bonds · protein-protein
- A–B · 5959 Ų buried · 167 hydrogen bonds · protein-protein
- A–C · 107 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7QWG · TMEM106B filaments with Fold IIa from Multiple system atrophy (case 19) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NUM4 · AlphaFold monomer V2.0 prediction for transmembrane protein 106B (Q9NUM4) · a predicted model of the same protein · chain A against A, TM-score 0.21
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NUM4
- Elsewhere: RCSB PDB 7QWG · PDBe 7QWG · UniProt Q9NUM4
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