UniProt Q9NUM4
Transmembrane protein 106B (Q9NUM4)
Transmembrane protein 106B (UniProt Q9NUM4): 45 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 134 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NUM4
- Protein
- Transmembrane protein 106B
- Experimental structures
- 45
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 134 · 24 records with a druggable one
Structures
46 records of Q9NUM4 in the MolNFT archive: 45 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7QVC | TMEM106B filaments with Fold I from Alzheimer's disease (case 1) | electron microscopy | A, B, C | — | 4 (best 0.52) |
| 7QVC | TMEM106B filaments with fold I from ALZHEIMER'S disease (case 1) | electron microscopy | A, B, C | — | — |
| 7QVF | TMEM106B filaments with Fold I-d from Multiple system atrophy (case 18) | electron microscopy | A, B, C, D, E, F | — | 8 (best 0.53) |
| 7QVF | TMEM106B filaments with fold I-D from multiple system atrophy (case 18) | electron microscopy | A, B, C, D, E, F | — | — |
| 7QWG | TMEM106B filaments with Fold IIa from Multiple system atrophy (case 19) | electron microscopy | A, B, C | — | 3 (best 0.53) |
| 7QWG | TMEM106B filaments with fold iia from multiple system atrophy (case 19) | electron microscopy | A, B, C | — | — |
| 7QWL | TMEM106B filaments with Fold IIb from Multiple system atrophy (case 19) | electron microscopy | A, B, C | — | 2 (best 0.54) |
| 7QWL | TMEM106B filaments with fold iib from multiple system atrophy (case 19) | electron microscopy | A, B, C | — | — |
| 7QWM | TMEM106B filaments with Fold III from Multiple system atrophy (case 17) | electron microscopy | A, B, C | — | 4 (best 0.50) |
| 7QWM | TMEM106B filaments with fold III from multiple system atrophy (case 17) | electron microscopy | A, B, C | — | — |
| 7SAQ | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1 | electron microscopy | A, B, C, D, E | NAG | — |
| 7SAQ | Cryo-EM structure of TMEM106B fibrils extracted from a ftld-tdp patient, polymorph 1 | electron microscopy | A, B, C, D, E | NAG | — |
| 7SAR | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2 | electron microscopy | A, B, C, D, E, F, G, H, I, J | NAG | 18 (best 0.76) |
| 7SAR | Cryo-EM structure of TMEM106B fibrils extracted from a ftld-tdp patient, polymorph 2 | electron microscopy | A, B, C, D, E, F, G, H, I, J | NAG | — |
| 7SAS | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3 | electron microscopy | A, B, C, D, E, F, G, H, I, J | NAG | 18 (best 0.76) |
| 7SAS | Cryo-EM structure of TMEM106B fibrils extracted from a ftld-tdp patient, polymorph 3 | electron microscopy | A, B, C, D, E, F, G, H, I, J | NAG | — |
| 7TMC | TMEM106B singlet filament extracted from MSTD neurodegenerative human brain | electron microscopy | A, B, C | NAG | 5 (best 0.57) |
| 7U10 | TMEM106B(120-254) protofilament from progressive supranuclear palsy (PSP) case 2 | electron microscopy | A, B, C | NAG | 4 (best 0.56) |
| 7U10 | TMEM106B(120-254) protofilament from progressive supranuclear palsy (psp) case 2 | electron microscopy | A, B, C | NAG | — |
| 7U11 | TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with TDP-43 pathology… | electron microscopy | A, B, C | NAG | 4 (best 0.55) |
| 7U11 | TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with tdp-43 pathology… | electron microscopy | A, B, C | NAG | — |
| 7U12 | TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43… | electron microscopy | A, B, C | NAG | 4 (best 0.55) |
| 7U12 | TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with tdp-43… | electron microscopy | A, B, C | NAG | — |
| 7U13 | TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43… | electron microscopy | A, B, C | NAG | 4 (best 0.57) |
| 7U13 | TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with tdp-43… | electron microscopy | A, B, C | NAG | — |
| 7U14 | TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43… | electron microscopy | A, B, C | NAG | 4 (best 0.56) |
| 7U14 | TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with tdp-43… | electron microscopy | A, B, C | NAG | — |
| 7U15 | TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43… | electron microscopy | B, A, C | NAG | 2 (best 0.54) |
| 7U15 | TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with tdp-43… | electron microscopy | B, A, C | NAG | — |
| 7U16 | TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with TDP-43 pathology… | electron microscopy | A, B, C | NAG | 4 (best 0.53) |
| 7U16 | TMEM106B(120-254) protofilament from frontotemporal lobar degeneration with tdp-43 pathology… | electron microscopy | A, B, C | NAG | — |
| 7U17 | TMEM106B(120-254) T185S singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43… | electron microscopy | B, A, C | NAG | 2 (best 0.54) |
| 7U17 | TMEM106B(120-254) T185S singlet amyloid fibril from frontotemporal lobar degeneration with tdp-43… | electron microscopy | B, A, C | NAG | — |
| 7X83 | Cryo-EM structure of the TMEM106B fibril from normal elder | electron microscopy | B, A, C | — | 3 (best 0.50) |
| 7X83 | Cryo-EM structure of the TMEM106B fibril from normal elder | electron microscopy | B, A, C | — | — |
| 7X84 | Cryo-EM structure of the TMEM106B fibril from Parkinson's disease dementia | electron microscopy | B, A, C | — | 4 (best 0.52) |
| 7X84 | Cryo-EM structure of the TMEM106B fibril from PARKINSON'S disease dementia | electron microscopy | B, A, C | — | — |
| 8B7D | Luminal domain of TMEM106B | x-ray diffraction | A | NAG | — |
| 8F9K | TMEM106B doublet filaments extracted from MSTD neurodegenerative human brain | electron microscopy | A, B, C, D, E, F | NAG | 8 (best 0.57) |
| 8J7N | The cryo-EM structure of Fe3+ induced alpha-syn fibril. | electron microscopy | A, B, C | — | 2 (best 0.58) |
| 8J7P | The cryo-EM structure of PiB bound TMEM106B fibril. | electron microscopy | B, A, C | — | 3 (best 0.49) |
| 8OTD | TMEM106B Fold1-s filament from Guam ALS/PDC | electron microscopy | A, B, C, D | — | 5 (best 0.70) |
| 8OTE | TMEM106B Fold I-d filament from Guam ALS/PDC | electron microscopy | A, B, C, D, E, F, G, H | — | 11 (best 0.69) |
| 8X5H | The cryo-EM structure of TMEM106B amyloid fibril in PD patient. | electron microscopy | B, A, C | — | 2 (best 0.59) |
| 9FNB | TMEM106B filaments from Biondi bodies (Biondi variant) | electron microscopy | B, A, C, D | NAG | 5 (best 0.69) |
| Q9NUM4 | AlphaFold monomer V2.0 prediction for transmembrane protein 106B (Q9NUM4) | predicted | A | — | 1 (best 0.38) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 26 records
Experiment against prediction
- 8B7D chain A against the predicted model Q9NUM4: TM-score 0.94, RMSD 1.55 Å
- 7SAR chain A against the predicted model Q9NUM4: TM-score 0.22, RMSD 5.62 Å
- 7SAR chain A against the predicted model Q9NUM4: TM-score 0.22, RMSD 5.62 Å
- 7SAS chain A against the predicted model Q9NUM4: TM-score 0.22, RMSD 5.83 Å
- 7SAS chain A against the predicted model Q9NUM4: TM-score 0.22, RMSD 5.83 Å
- 7U16 chain A against the predicted model Q9NUM4: TM-score 0.22, RMSD 5.83 Å
- 7U16 chain A against the predicted model Q9NUM4: TM-score 0.22, RMSD 5.83 Å
- 7QVC chain B against the predicted model Q9NUM4: TM-score 0.22, RMSD 5.70 Å
- 7X84 chain B against the predicted model Q9NUM4: TM-score 0.22, RMSD 5.78 Å
- 7X84 chain B against the predicted model Q9NUM4: TM-score 0.22, RMSD 5.78 Å
Elsewhere
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