MolNFT v1 · #190471 · protein
Cryo-EM structure of the TMEM106B fibril from PARKINSON'S disease dementia
7X84 · Transmembrane protein 106B: “Cryo-EM structure of the TMEM106B fibril from PARKINSON'S disease dementia”. Electron microscopy, 4 pockets (best druggability 0.52). MolNFT v1 #190471 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7X84
- Type
- protein
- Length
- 405 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transmembrane protein 106B
- UniProt
- Q9NUM4
- Pockets
- 4 · best druggability 0.52
Structure
electron microscopy · 1 distinct chain · 0% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, C | Transmembrane protein 106B | protein | 135 | 0% helix, 44% strand | Q9NUM4 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.52 | 0.82 | 21 | empty |
| 2 | 238 | 0.51 | 0.76 | 26 | empty |
| 3 | 132 | 0.50 | 0.79 | 19 | empty |
| 4 | 232 | 0.48 | 0.74 | 34 | empty |
Interfaces
3 interfaces between chains.
- B–A · 5838 Ų buried · 154 hydrogen bonds · protein-protein
- A–C · 5831 Ų buried · 152 hydrogen bonds · protein-protein
- B–C · 85 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7X84 · Cryo-EM structure of the TMEM106B fibril from Parkinson's disease dementia · the same entry in another collection · chain B against B, TM-score 1.00
- Q9NUM4 · AlphaFold monomer V2.0 prediction for transmembrane protein 106B (Q9NUM4) · a predicted model of the same protein · chain B against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NUM4
- Elsewhere: RCSB PDB 7X84 · PDBe 7X84 · UniProt Q9NUM4
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