Research workbench
In vitro assembled 266/297 - 391 tau filaments with MGCL2 and nacl (14A)
Analyse In vitro assembled 266/297 - 391 tau filaments with MGCL2 and nacl (14A) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QKU
- Type
- protein
- Length
- 453 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 3 · best druggability 0.56
Structure
electron microscopy · 2 distinct chains · 0% helix, 64% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | Microtubule-associated protein tau | protein | 76 | 0% helix, 64% strand | P10636 |
| C, E, F | Microtubule-associated protein tau | protein | 75 | 0% helix, 63% strand | P10636 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 231 | 0.56 | 0.78 | 30 | empty |
| 2 | 148 | 0.54 | 0.80 | 22 | empty |
| 3 | 124 | 0.49 | 0.79 | 17 | empty |
Interfaces
15 interfaces between chains.
- A–D · 3158 Ų buried · 88 hydrogen bonds · protein-protein
- B–D · 3148 Ų buried · 91 hydrogen bonds · protein-protein
- C–F · 3147 Ų buried · 84 hydrogen bonds · protein-protein
- C–E · 3131 Ų buried · 86 hydrogen bonds · protein-protein
- A–C · 150 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7QKU · in vitro assembled 266/297 - 391 tau filaments with MgCl2 and NaCl (14a) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7QKU · PDBe 7QKU · UniProt P10636
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