Research workbench
In vitro assembled 266/297 - 391 tau filaments with MGCL2 and nacl (14B)
Analyse In vitro assembled 266/297 - 391 tau filaments with MGCL2 and nacl (14B) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QKJ
- Type
- protein
- Length
- 900 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 11 · best druggability 0.53
Structure
electron microscopy · 1 distinct chain · 0% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Microtubule-associated protein tau | protein | 75 | 0% helix, 53% strand | P10636 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.53 | 0.79 | 25 | empty |
| 2 | 147 | 0.53 | 0.79 | 24 | empty |
| 3 | 145 | 0.53 | 0.79 | 24 | empty |
| 4 | 163 | 0.53 | 0.79 | 25 | empty |
| 5 | 91 | 0.46 | 0.80 | 15 | empty |
Interfaces
30 interfaces between chains.
- B–C · 3176 Ų buried · 79 hydrogen bonds · protein-protein
- A–C · 3170 Ų buried · 81 hydrogen bonds · protein-protein
- G–I · 3153 Ų buried · 80 hydrogen bonds · protein-protein
- D–F · 3141 Ų buried · 76 hydrogen bonds · protein-protein
- D–E · 3140 Ų buried · 82 hydrogen bonds · protein-protein
Compared structures
- 7QKJ · In vitro assembled 266/297 - 391 tau filaments with MgCl2 and NaCl (14b) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7QKJ · PDBe 7QKJ · UniProt P10636
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