Research workbench
In vitro assembled 266/297 - 391 tau filaments with kcl (10A)
Analyse In vitro assembled 266/297 - 391 tau filaments with kcl (10A) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QK5
- Type
- protein
- Length
- 666 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Ligands
- K, CL
- Pockets
- 5 · best druggability 0.55
Structure
electron microscopy · 1 distinct chain · 0% helix, 66% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, K, B, C, D, E, F, G, H | Microtubule-associated protein tau | protein | 74 | 0% helix, 66% strand | P10636 |
Ligands and binding sites
- K · Potassium ion · metal · 18 copies · chains A, C, F, K, D, B, E, G, H
- CL · Chloride ion · ion · 18 copies · chains A, F, K, D, G, B, H, E, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 138 | 0.55 | 0.81 | 22 | CL, K |
| 2 | 138 | 0.54 | 0.80 | 22 | K, CL |
| 3 | 87 | 0.51 | 0.84 | 18 | empty |
| 4 | 140 | 0.51 | 0.79 | 23 | K, CL |
| 5 | 63 | 0.34 | 0.77 | 18 | empty |
Interfaces
17 interfaces between chains.
- A–C · 3166 Ų buried · 85 hydrogen bonds · protein-protein
- K–D · 3163 Ų buried · 83 hydrogen bonds · protein-protein
- K–G · 3160 Ų buried · 86 hydrogen bonds · protein-protein
- B–E · 3159 Ų buried · 84 hydrogen bonds · protein-protein
- B–H · 3156 Ų buried · 85 hydrogen bonds · protein-protein
Compared structures
- 7QK5 · In vitro assembled 266/297 - 391 tau filaments with KCl (10a) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7QK5 · PDBe 7QK5 · UniProt P10636
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