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In vitro assembled 297-394 tau filaments, 700 rpm (34B)

Analyse In vitro assembled 297-394 tau filaments, 700 rpm (34B) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7QJX
Type: protein
Length: 900 residues
Chains: 12
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated protein tau
UniProt: P10636
Pockets: 13 · best druggability 0.56

Structure

electron microscopy · 1 distinct chain · 0% helix, 71% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L	Microtubule-associated protein tau	protein	75	0% helix, 71% strand	P10636

Pockets

13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	275	0.56	0.77	31	empty
2	262	0.55	0.77	31	empty
3	247	0.55	0.77	30	empty
4	254	0.55	0.77	32	empty
5	80	0.48	0.83	20	empty

Interfaces

23 interfaces between chains.

J–L · 3231 Å² buried · 80 hydrogen bonds · protein-protein
K–L · 3213 Å² buried · 83 hydrogen bonds · protein-protein
E–F · 3191 Å² buried · 80 hydrogen bonds · protein-protein
D–F · 3184 Å² buried · 77 hydrogen bonds · protein-protein
G–I · 3165 Å² buried · 83 hydrogen bonds · protein-protein

Compared structures

7QJX · In vitro assembled 297-394 tau filaments, 700 rpm (34b) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10636
Elsewhere: RCSB PDB 7QJX · PDBe 7QJX · UniProt P10636

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