Research workbench

Structure of recombinant human gamma-tubulin ring complex 10-spoked assembly intermediate (spokes 3-12, homogeneous dataset)

Analyse Structure of recombinant human gamma-tubulin ring complex 10-spoked assembly… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7QJ9
Type: protein
Length: 11,326 residues
Chains: 31
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gamma-tubulin complex component 5; Actin, cytoplasmic 1; Mitotic-spindle organizing…
UniProt: Q96RT8, A0A6I9HGD1, Q08AG7, Q96CW5, Q9BSJ2, Q9UGJ1, Q96RT7, P23258
Pockets: 20 · best druggability 0.90

Structure

electron microscopy · 19 distinct chains · 59% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
l	Gamma-tubulin complex component 5	protein	108	67% helix, 0% strand	Q96RT8
e	Actin, cytoplasmic 1	protein	364	44% helix, 14% strand	A0A6I9HGD1
b, i, m, k	Mitotic-spindle organizing protein 1	protein	65	71% helix, 0% strand	Q08AG7
a	Gamma-tubulin complex component 3	protein	116	54% helix, 0% strand	Q96CW5
C	Gamma-tubulin complex component 2	protein	620	56% helix, 3% strand	Q9BSJ2
D	Gamma-tubulin complex component 3	protein	581	63% helix, 4% strand	Q96CW5
E	Gamma-tubulin complex component 2	protein	638	58% helix, 3% strand	Q9BSJ2
F	Gamma-tubulin complex component 3	protein	599	60% helix, 2% strand	Q96CW5
G	Gamma-tubulin complex component 2	protein	640	60% helix, 3% strand	Q9BSJ2
H	Gamma-tubulin complex component 3	protein	594	67% helix, 3% strand	Q96CW5
I	Gamma-tubulin complex component 4	protein	521	64% helix, 2% strand	Q9UGJ1
J	Gamma-tubulin complex component 5	protein	534	63% helix, 0% strand	Q96RT8
K	Gamma-tubulin complex component 4	protein	562	65% helix, 1% strand	Q9UGJ1
L	Gamma-tubulin complex component 6	protein	566	58% helix, 1% strand	Q96RT7
h	Gamma-tubulin complex component 3	protein	99	63% helix, 0% strand	Q96CW5
Q, R, S, T, U, V, W, X, Y, Z	Tubulin gamma-1 chain	protein	420	44% helix, 16% strand	P23258
d	Mitotic-spindle organizing protein 1	protein	59	73% helix, 0% strand	Q08AG7
c	Gamma-tubulin complex component 6	protein	158	55% helix, 0% strand	Q96RT7
j	Gamma-tubulin complex component 3	protein	107	58% helix, 0% strand	Q96CW5

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	963	0.90	0.91	149	empty
2	689	0.86	0.90	89	empty
3	720	0.84	0.88	121	empty
4	710	0.84	0.88	106	empty
5	1069	0.84	0.85	138	empty

Interfaces

62 interfaces between chains.

C–Q · 2295 Å² buried · 12 hydrogen bonds · protein-protein
K–L · 2294 Å² buried · 18 hydrogen bonds · protein-protein
H–V · 2183 Å² buried · 14 hydrogen bonds · protein-protein
i–h · 2154 Å² buried · 10 hydrogen bonds · protein-protein
k–j · 2139 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

7QJ9 · Structure of recombinant human gamma-Tubulin Ring Complex 10-spoked assembly intermediate… · the same entry in another collection · chain I against I, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96RT8
Every structure of UniProt A0A6I9HGD1
Every structure of UniProt Q08AG7
Every structure of UniProt Q96CW5
Every structure of UniProt Q9BSJ2
Every structure of UniProt Q9UGJ1
Every structure of UniProt Q96RT7
Every structure of UniProt P23258
Elsewhere: RCSB PDB 7QJ9 · PDBe 7QJ9 · UniProt Q96RT8 · UniProt A0A6I9HGD1 · UniProt Q08AG7 · UniProt Q96CW5 · UniProt Q9BSJ2 · UniProt Q9UGJ1 · UniProt Q96RT7 · UniProt P23258

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.