Research workbench
Homology model of myosin neck domain in skeletal sarcomere
Analyse Homology model of myosin neck domain in skeletal sarcomere in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QIO
- Type
- protein
- Length
- 678 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-4; Myosin light chain 1/3, skeletal muscle isoform; Myosin regulatory light chain…
- UniProt
- Q5SX39, P05977, P97457
- Pockets
- 7 · best druggability 0.62
Structure
electron microscopy · 3 distinct chains · 58% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, M | Myosin-4 | protein | 48 | 83% helix, 0% strand | Q5SX39 |
| N, O | Myosin light chain 1/3, skeletal muscle isoform | protein | 148 | 56% helix, 5% strand | P05977 |
| P, Q | Myosin regulatory light chain 2, skeletal muscle isoform | protein | 143 | 50% helix, 1% strand | P97457 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 199 | 0.62 | 0.82 | 30 | empty |
| 2 | 273 | 0.60 | 0.79 | 37 | empty |
| 3 | 193 | 0.56 | 0.79 | 24 | empty |
| 4 | 340 | 0.54 | 0.74 | 44 | empty |
| 5 | 181 | 0.47 | 0.76 | 25 | empty |
Interfaces
8 interfaces between chains.
- M–Q · 1721 Ų buried · 18 hydrogen bonds · protein-protein
- L–P · 1647 Ų buried · 15 hydrogen bonds · protein-protein
- L–N · 1279 Ų buried · 16 hydrogen bonds · protein-protein
- M–O · 1241 Ų buried · 16 hydrogen bonds · protein-protein
- P–Q · 175 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7QIO · Homology model of myosin neck domain in skeletal sarcomere · the same entry in another collection · chain Q against Q, TM-score 1.00
- P05977 · AlphaFold monomer V2.0 prediction for myosin light chain 1/3, skeletal muscle isoform… · a predicted model of the same protein · chain N against A, TM-score 0.90
- Q5SX39 · AlphaFold monomer V2.0 prediction for myosin-4 (Q5SX39) · a predicted model of the same protein · chain L against A, TM-score 0.68
- P97457 · AlphaFold monomer V2.0 prediction for myosin regulatory light chain 2, skeletal muscle… · a predicted model of the same protein · chain P against A, TM-score 0.55
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SX39
- Every structure of UniProt P05977
- Every structure of UniProt P97457
- Elsewhere: RCSB PDB 7QIO · PDBe 7QIO · UniProt Q5SX39 · UniProt P05977 · UniProt P97457
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