Research workbench
Human topoisomerase II beta ATPase amppnp
Analyse Human topoisomerase II beta ATPase amppnp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QFO
- Type
- protein
- Length
- 379 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA topoisomerase 2-beta
- EC
- 5.6.2.2
- UniProt
- Q02880
- Ligands
- ALA, ANP, MG
- Pockets
- 5 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 2-beta (EC 5.6.2.2) | protein | 379 | 31% helix, 28% strand | Q02880 |
Ligands and binding sites
- ALA · Alanine · ligand · chains A
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 282 | 0.74 | 0.87 | 40 | ANP, MG |
| 2 | 267 | 0.63 | 0.81 | 32 | empty |
| 3 | 55 | 0.44 | 0.83 | 15 | empty |
| 4 | 70 | 0.35 | 0.77 | 13 | empty |
| 5 | 60 | 0.33 | 0.77 | 16 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02880
- Elsewhere: RCSB PDB 7QFO · PDBe 7QFO · UniProt Q02880
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