UniProt Q02880
DNA topoisomerase 2-beta (Q02880)
DNA topoisomerase 2-beta (UniProt Q02880), EC 5.6.2.2, 5.99.1.3: 31 experimental structures on GenesisL1, 12 ligands bound, 110 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q02880
- Protein
- DNA topoisomerase 2-beta
- EC
- 5.6.2.2, 5.99.1.3
- Experimental structures
- 31
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 110 · 10 records with a druggable one
Structures
31 records of Q02880 in the MolNFT archive: 31 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3QX3 | Human topoisomerase IIbeta in complex with DNA and etoposide | x-ray diffraction | A, B | — | — |
| 3QX3 | Human topoisomerase iibeta in complex with DNA and etoposide | x-ray diffraction | A, B | — | — |
| 4G0U | Human topoisomerase IIbeta in complex with DNA and amsacrine | x-ray diffraction | A, B | — | — |
| 4G0U | Human topoisomerase iibeta in complex with DNA and amsacrine | x-ray diffraction | A, B | — | — |
| 4G0V | Human topoisomerase iibeta in complex with DNA and mitoxantrone | x-ray diffraction | A, B | — | — |
| 4G0V | Human topoisomerase iibeta in complex with DNA and mitoxantrone | x-ray diffraction | A, B | — | — |
| 4G0W | Human topoisomerase iibeta in complex with DNA and ametantrone | x-ray diffraction | A, B | — | — |
| 4G0W | Human topoisomerase iibeta in complex with DNA and ametantrone | x-ray diffraction | A, B | — | — |
| 4J3N | Human Topoisomerase Iibeta in complex with DNA | x-ray diffraction | A, B | — | — |
| 4J3N | Human topoisomerase iibeta in complex with DNA | x-ray diffraction | A, B | — | — |
| 5GWI | Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R | x-ray diffraction | A, B | N2R, N2N, MG | 18 (best 0.88) |
| 5GWI | Structure of a human topoisomerase iibeta fragment in complex with DNA and E7873R | x-ray diffraction | A, B | — | — |
| 5GWJ | Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873S | x-ray diffraction | A, B | N2S, N2W, MG | 17 (best 0.85) |
| 5GWJ | Structure of a human topoisomerase iibeta fragment in complex with DNA and E7873S | x-ray diffraction | A, B | — | — |
| 5ZAD | Human topoisomerase II beta in complex with DNA | x-ray diffraction | A, B | — | — |
| 5ZAD | Human topoisomerase II beta in complex with DNA | x-ray diffraction | A, B | — | — |
| 5ZEN | Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation… | x-ray diffraction | A | MN | 11 (best 0.75) |
| 5ZEN | Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation… | x-ray diffraction | A | MN | — |
| 5ZQF | Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA in… | x-ray diffraction | A | MN | 8 (best 0.81) |
| 5ZQF | Crystal structure of human topoisomerase II beta in complex with 5- iodouridine-containing-DNA in… | x-ray diffraction | A | MN | — |
| 5ZRF | Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and… | x-ray diffraction | A, B | MG, EVP | 10 (best 0.83) |
| 5ZRF | Crystal structure of human topoisomerase II beta in complex with 5- iodouridine-containing-DNA and… | x-ray diffraction | A, B | MG, EVP | — |
| 7QFN | Human Topoisomerase II Beta ATPase ADP | x-ray diffraction | A | ADP, SO4, MG | 3 (best 0.74) |
| 7QFN | Human topoisomerase II beta ATPase ADP | x-ray diffraction | A | ADP, SO4, MG | — |
| 7QFO | Human Topoisomerase II Beta ATPase AMPPNP | x-ray diffraction | A | ALA, ANP, MG | 5 (best 0.74) |
| 7QFO | Human topoisomerase II beta ATPase amppnp | x-ray diffraction | A | ANP, MG | — |
| 7YQ8 | Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide | electron microscopy | A, B | MG, EVP | 20 (best 0.83) |
| 7ZBG | Human Topoisomerase II Beta ATPase ADP | x-ray diffraction | A | ADP, SO4, MG, ITH | 4 (best 0.77) |
| 7ZBG | Human topoisomerase II beta ATPase ADP | x-ray diffraction | A | ADP, SO4, MG, ITH | — |
| 8KE7 | Crystal structure of DNA binding and cleavage core of human topoisomerase 2-beta in a DNA… | x-ray diffraction | A, B | — | 14 (best 0.77) |
| Q02880 | AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-beta (Q02880) | — | — | — |
Ligands
- MG · Magnesium ion · in 11 records
- ADP · Adenosine-5'-diphosphate · in 4 records
- MN · Manganese (II) ion · in 4 records
- SO4 · Sulfate ion · in 4 records
- EVP · (5s,5ar,8ar,9r)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5A,6,8,8A,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside · in 3 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- ITH · 4-[(2S,3R)-3-[3,5-bis(oxidanylidene)piperazin-1-ium-1-yl]butan-2-yl]piperazin-4-ium-2,6-dione · in 2 records
- ALA · Alanine · in 1 record
- N2N · dichloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum · in 1 record
- N2R · dichloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum · in 1 record
- N2S · chloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum · in 1 record
- N2W · chloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum · in 1 record
Elsewhere
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