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Structure of tev cleaved A2ML1 (A2ML1-te)

Analyse Structure of tev cleaved A2ML1 (A2ML1-te) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7Q60
Type: protein
Length: 1,212 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-2-macroglobulin-like protein 1
UniProt: A8K2U0
Pockets: 17 · best druggability 0.74

Structure

electron microscopy · 1 distinct chain · 13% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-2-macroglobulin-like protein 1	protein	1212	13% helix, 40% strand	A8K2U0

Pockets

17 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.74	0.97	19	empty
2	275	0.73	0.86	43	empty
3	57	0.72	0.97	18	empty
4	388	0.68	0.81	47	empty
5	225	0.65	0.84	39	empty

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

7Q60 · Structure of TEV cleaved A2ML1 (A2ML1-TE) · the same entry in another collection · chain A against A, TM-score 1.00
A8K2U0 · AlphaFold monomer V2.0 prediction for alpha-2-macroglobulin-like protein 1 (A8K2U0) · a predicted model of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A8K2U0
Elsewhere: RCSB PDB 7Q60 · PDBe 7Q60 · UniProt A8K2U0

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