UniProt A8K2U0
Alpha-2-macroglobulin-like protein 1 (A8K2U0)
Alpha-2-macroglobulin-like protein 1 (UniProt A8K2U0): 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 77 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- A8K2U0
- Protein
- Alpha-2-macroglobulin-like protein 1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 77 · 4 records with a druggable one
Structures
11 records of A8K2U0 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7Q1Y | X-ray structure of human A2ML1 | x-ray diffraction | A, B | NAG, BMA | 20 (best 0.75) |
| 7Q1Y | X-ray structure of human A2ML1 | x-ray diffraction | A, B | NAG, BMA | — |
| 7Q5Z | Cryo-EM structure of native human A2ML1 | electron microscopy | A | — | 20 (best 0.71) |
| 7Q5Z | Cryo-EM structure of native human A2ML1 | electron microscopy | A | — | — |
| 7Q60 | Structure of TEV cleaved A2ML1 (A2ML1-TE) | electron microscopy | A | — | 17 (best 0.74) |
| 7Q60 | Structure of tev cleaved A2ML1 (A2ML1-te) | electron microscopy | A | — | — |
| 7Q61 | Structure of TEV conjugated A2ML1 (A2ML1-TC) | electron microscopy | A | NAG | — |
| 7Q61 | Structure of tev conjugated A2ML1 (A2ML1-tc) | electron microscopy | A | NAG | — |
| 7Q62 | Structure of TEV cleaved A2ML1 dimer (A2ML1-TT dimer) | electron microscopy | A, B | NAG | 20 (best 0.82) |
| 7Q62 | Structure of tev cleaved A2ML1 dimer (A2ML1-tt dimer) | electron microscopy | A, B | NAG | — |
| A8K2U0 | AlphaFold monomer V2.0 prediction for alpha-2-macroglobulin-like protein 1 (A8K2U0) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7Q1Y chain B against the predicted model A8K2U0: TM-score 0.95, RMSD 2.79 Å
- 7Q1Y chain B against the predicted model A8K2U0: TM-score 0.95, RMSD 2.79 Å
- 7Q1Y chain A against the predicted model A8K2U0: TM-score 0.94, RMSD 2.99 Å
- 7Q1Y chain A against the predicted model A8K2U0: TM-score 0.94, RMSD 2.99 Å
- 7Q62 chain B against the predicted model A8K2U0: TM-score 0.93, RMSD 2.94 Å
- 7Q62 chain B against the predicted model A8K2U0: TM-score 0.93, RMSD 2.94 Å
- 7Q5Z chain A against the predicted model A8K2U0: TM-score 0.92, RMSD 3.69 Å
- 7Q5Z chain A against the predicted model A8K2U0: TM-score 0.92, RMSD 3.69 Å
- 7Q60 chain A against the predicted model A8K2U0: TM-score 0.69, RMSD 4.44 Å
- 7Q60 chain A against the predicted model A8K2U0: TM-score 0.69, RMSD 4.44 Å
Elsewhere
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