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Cryo-EM structure of native human A2ML1

Analyse Cryo-EM structure of native human A2ML1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7Q5Z
Type: protein
Length: 1,344 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-2-macroglobulin-like protein 1
UniProt: A8K2U0
Pockets: 20 · best druggability 0.71

Structure

electron microscopy · 1 distinct chain · 14% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-2-macroglobulin-like protein 1	protein	1344	14% helix, 37% strand	A8K2U0

Pockets

20 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.71	0.97	20	empty
2	773	0.69	0.76	68	empty
3	228	0.67	0.85	28	empty
4	320	0.64	0.80	40	empty
5	101	0.49	0.81	24	empty

Modifications

Observed in the structure: 11 disulfide (disulfide).

Compared structures

7Q5Z · Cryo-EM structure of native human A2ML1 · the same entry in another collection · chain A against A, TM-score 1.00
A8K2U0 · AlphaFold monomer V2.0 prediction for alpha-2-macroglobulin-like protein 1 (A8K2U0) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A8K2U0
Elsewhere: RCSB PDB 7Q5Z · PDBe 7Q5Z · UniProt A8K2U0

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