Type I beta-amyloid 42 filaments from human brain

Structure

electron microscopy · 1 distinct chain · 0% helix, 56% strand (DSSP).

Ligands and binding sites

• UNX · Unknown atom or ion · ion · 10 copies · chains R, D, A, E, B, C, F, G, H, I

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

31 interfaces between chains.

• B–F · 1345 Ų buried · 38 hydrogen bonds · protein-protein
• R–B · 1341 Ų buried · 36 hydrogen bonds · protein-protein
• C–G · 1339 Ų buried · 37 hydrogen bonds · protein-protein
• A–C · 1333 Ų buried · 35 hydrogen bonds · protein-protein
• R–D · 1333 Ų buried · 35 hydrogen bonds · protein-protein

Compared structures

• 7Q4B · Type I beta-amyloid 42 Filaments from Human Brain · the same entry in another collection · chain I against I, TM-score 1.00
• P05067 · AlphaFold monomer V2.0 prediction for amyloid-beta precursor protein (P05067) · a predicted model of the same protein · chain C against A, TM-score 0.31

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P05067
• Elsewhere: RCSB PDB 7Q4B · PDBe 7Q4B · UniProt P05067