Research workbench
Structure of thermostabilised human ntcp in complex with nanobody 87
Analyse Structure of thermostabilised human ntcp in complex with nanobody 87 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PQG
- Type
- protein
- Length
- 423 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nanobody 87; SODIUM/BILE acid cotransporter
- UniProt
- Q14973
- Pockets
- 9 · best druggability 0.78
Structure
electron microscopy · 2 distinct chains · 60% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Nanobody 87 | protein | 124 | 7% helix, 34% strand | — |
| A | SODIUM/BILE acid cotransporter | protein | 299 | 82% helix, 0% strand | Q14973 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 109 | 0.78 | 0.97 | 26 | empty |
| 2 | 399 | 0.67 | 0.79 | 52 | empty |
| 3 | 189 | 0.66 | 0.84 | 20 | empty |
| 4 | 163 | 0.66 | 0.86 | 31 | empty |
| 5 | 151 | 0.51 | 0.79 | 26 | empty |
Interfaces
1 interface between chains.
- B–A · 836 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7PQG · Structure of thermostabilised human NTCP in complex with nanobody 87 · the same entry in another collection · chain B against B, TM-score 1.00
- Q14973 · AlphaFold monomer V2.0 prediction for SODIUM/BILE acid cotransporter (Q14973) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14973
- Elsewhere: RCSB PDB 7PQG · PDBe 7PQG · UniProt Q14973
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