UniProt Q14973
Sodium/bile acid cotransporter (Q14973)
Sodium/bile acid cotransporter (UniProt Q14973): 17 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 58 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q14973
- Protein
- Sodium/bile acid cotransporter
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 58 · 11 records with a druggable one
Structures
18 records of Q14973 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7FCI | human NTCP in complex with YN69083 Fab | electron microscopy | A | — | 5 (best 0.76) |
| 7FCI | Human ntcp in complex with YN69083 Fab | electron microscopy | A | — | — |
| 7PQG | Structure of thermostabilised human NTCP in complex with nanobody 87 | electron microscopy | A | — | 9 (best 0.78) |
| 7PQG | Structure of thermostabilised human ntcp in complex with nanobody 87 | electron microscopy | A | — | — |
| 7PQQ | Structure of thermostabilised human NTCP in complex with Megabody 91 | electron microscopy | A | — | 3 (best 0.74) |
| 7PQQ | Structure of thermostabilised human ntcp in complex with megabody 91 | electron microscopy | A | — | — |
| 7VAD | Cryo-EM structure of human NTCP complexed with YN69202Fab | electron microscopy | A | — | 6 (best 0.71) |
| 7VAD | Cryo-EM structure of human ntcp complexed with YN69202FAB | electron microscopy | A | — | — |
| 7VAG | Cryo-EM structure of human NTCP complexed with YN69202Fab in the presence of myristoylated preS1… | electron microscopy | A | — | 6 (best 0.76) |
| 7VAG | Cryo-EM structure of human ntcp complexed with YN69202FAB in the presence of myristoylated PRES1… | electron microscopy | A | — | — |
| 7WSI | Cryo-EM structure of human NTCP (wild-type) complexed with YN69202Fab | electron microscopy | A | — | 5 (best 0.71) |
| 7WSI | Cryo-EM structure of human ntcp (wild-type) complexed with YN69202FAB | electron microscopy | A | — | — |
| 7ZYI | Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody | electron microscopy | A | CLR, CHO, NA | 4 (best 0.76) |
| 7ZYI | Structure of the human SODIUM/BILE acid cotransporter (ntcp) in complex with Fab and nanobody | electron microscopy | A | CLR, CHO, NA | — |
| 8HRX | Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex | electron microscopy | A | — | 5 (best 0.75) |
| 8HRY | Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex | electron microscopy | A | — | 5 (best 0.69) |
| 8RQF | Cryo-EM structure of human NTCP-Bulevirtide complex | electron microscopy | A | BJU | 7 (best 0.71) |
| Q14973 | AlphaFold monomer V2.0 prediction for SODIUM/BILE acid cotransporter (Q14973) | predicted | A | — | 3 (best 0.57) |
Ligands
Experiment against prediction
- 7PQG chain A against the predicted model Q14973: TM-score 0.93, RMSD 1.94 Å
- 7PQG chain A against the predicted model Q14973: TM-score 0.93, RMSD 1.94 Å
- 7ZYI chain A against the predicted model Q14973: TM-score 0.81, RMSD 3.01 Å
- 7ZYI chain A against the predicted model Q14973: TM-score 0.81, RMSD 3.01 Å
- 7WSI chain A against the predicted model Q14973: TM-score 0.80, RMSD 3.14 Å
- 7WSI chain A against the predicted model Q14973: TM-score 0.80, RMSD 3.14 Å
- 7FCI chain A against the predicted model Q14973: TM-score 0.79, RMSD 3.26 Å
- 7FCI chain A against the predicted model Q14973: TM-score 0.79, RMSD 3.26 Å
- 7VAD chain A against the predicted model Q14973: TM-score 0.79, RMSD 3.20 Å
- 7VAD chain A against the predicted model Q14973: TM-score 0.79, RMSD 3.20 Å
Elsewhere
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