Research workbench
Autoinhibited structure of human neurofibromin isoform 2 stabilized by zinc.
Analyse Autoinhibited structure of human neurofibromin isoform 2 stabilized by zinc. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PGU
- Type
- protein
- Length
- 4,846 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurofibromin
- UniProt
- P21359
- Ligands
- PEV, ZN
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 63% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F, N | Neurofibromin | protein | 2423 | 63% helix, 3% strand | P21359 |
Ligands and binding sites
- PEV · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · ligand · 2 copies · chains F, N
- ZN · Zinc ion · metal · 2 copies · chains F, N
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 750 | 0.86 | 0.88 | 40 | PEV |
| 2 | 737 | 0.86 | 0.88 | 46 | PEV |
| 3 | 521 | 0.75 | 0.83 | 65 | empty |
| 4 | 361 | 0.74 | 0.85 | 62 | empty |
| 5 | 341 | 0.71 | 0.84 | 56 | empty |
Interfaces
1 interface between chains.
- F–N · 5822 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 7PGU · Autoinhibited structure of human neurofibromin isoform 2 stabilized by Zinc. · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21359
- Elsewhere: RCSB PDB 7PGU · PDBe 7PGU · UniProt P21359
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.