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The structure of human neurofibromin isoform 2 in opened conformation.

Analyse The structure of human neurofibromin isoform 2 in opened conformation. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7PGT
Type: protein
Length: 4,846 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurofibromin
UniProt: P21359
Ligands: ZN
Pockets: 20 · best druggability 0.86

Structure

electron microscopy · 1 distinct chain · 65% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
N, F	Neurofibromin	protein	2423	65% helix, 2% strand	P21359

Ligands and binding sites

ZN · Zinc ion · metal · chains F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	669	0.86	0.89	44	empty
2	453	0.85	0.92	46	empty
3	1132	0.79	0.81	107	empty
4	1180	0.75	0.77	110	empty
5	453	0.73	0.83	62	empty

Interfaces

1 interface between chains.

N–F · 5190 Å² buried · 33 hydrogen bonds · protein-protein

Compared structures

7PGT · The structure of human neurofibromin isoform 2 in opened conformation. · the same entry in another collection · chain N against N, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21359
Elsewhere: RCSB PDB 7PGT · PDBe 7PGT · UniProt P21359

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