Research workbench
Structure of adenylyl cyclase 9 in complex with gs protein alpha subunit and mant-GTP
Analyse Structure of adenylyl cyclase 9 in complex with gs protein alpha subunit and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PDE
- Type
- protein
- Length
- 1,187 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylate cyclase 9; Guanine nucleotide-binding protein G(S) subunit alpha isoforms short
- UniProt
- E1BM79, P04896
- Ligands
- GSP, MG
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 55% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylate cyclase 9 | protein | 846 | 58% helix, 12% strand | E1BM79 |
| B | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 341 | 48% helix, 10% strand | P04896 |
Ligands and binding sites
- GSP · 5'-guanosine-diphosphate-monothiophosphate · ligand · chains B
- MG · Magnesium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 331 | 0.81 | 0.90 | 53 | empty |
| 2 | 113 | 0.79 | 0.97 | 24 | empty |
| 3 | 232 | 0.78 | 0.92 | 37 | empty |
| 4 | 908 | 0.78 | 0.81 | 96 | empty |
| 5 | 911 | 0.77 | 0.80 | 89 | empty |
Interfaces
1 interface between chains.
- A–B · 1005 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7PDE · Structure of Adenylyl cyclase 9 in complex with Gs protein alpha subunit and MANT-GTP · the same entry in another collection · chain A against A, TM-score 1.00
- P04896 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E1BM79
- Every structure of UniProt P04896
- Elsewhere: RCSB PDB 7PDE · PDBe 7PDE · UniProt E1BM79 · UniProt P04896
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