Research workbench
Escherichia COLI type II L-asparaginase
Analyse Escherichia COLI type II L-asparaginase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7P9C
- Type
- protein
- Length
- 1,269 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-asparaginase 2
- EC
- 3.5.1.1
- UniProt
- P00805
- Pockets
- 13 · best druggability 0.66
Structure
x-ray diffraction · 4 distinct chains · 34% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-asparaginase 2 (EC 3.5.1.1) | protein | 321 | 33% helix, 21% strand | P00805 |
| B | L-asparaginase 2 (EC 3.5.1.1) | protein | 311 | 34% helix, 22% strand | P00805 |
| C | L-asparaginase 2 (EC 3.5.1.1) | protein | 326 | 33% helix, 21% strand | P00805 |
| D | L-asparaginase 2 (EC 3.5.1.1) | protein | 311 | 34% helix, 22% strand | P00805 |
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.66 | 0.88 | 30 | empty |
| 2 | 156 | 0.66 | 0.87 | 30 | empty |
| 3 | 162 | 0.56 | 0.81 | 25 | empty |
| 4 | 308 | 0.55 | 0.76 | 34 | empty |
| 5 | 247 | 0.54 | 0.77 | 29 | empty |
Interfaces
3 interfaces between chains.
- C–D · 2078 Ų buried · 39 hydrogen bonds · protein-protein
- A–B · 2059 Ų buried · 39 hydrogen bonds · protein-protein
- A–C · 764 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00805
- Elsewhere: RCSB PDB 7P9C · PDBe 7P9C · UniProt P00805
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