UniProt P00805
L-asparaginase 2 (P00805)
L-asparaginase 2 (UniProt P00805), EC 3.5.1.1: 74 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 304 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00805
- Protein
- L-asparaginase 2
- EC
- 3.5.1.1
- Experimental structures
- 74
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 304 · 27 records with a druggable one
Structures
75 records of P00805 in the MolNFT archive: 74 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HO3 | Crystal structure analysis of E. COLI L-asparaginase II (Y25F mutant) | x-ray diffraction | A, B | — | — |
| 1HO3 | Crystal structure analysis of E. COLI L-asparaginase II (Y25F mutant) | x-ray diffraction | A, B | — | — |
| 1IHD | Crystal Structure of Trigonal Form of D90E Mutant of Escherichia coli Asparaginase II | x-ray diffraction | A, C | — | — |
| 1IHD | Crystal structure of trigonal form of D90E mutant of escherichia COLI asparaginase II | x-ray diffraction | A, C | — | — |
| 1JAZ | Crystal Structure of Monoclinic Form of D90E Mutant of Escherichia coli Asparaginase II | x-ray diffraction | A, B | — | — |
| 1JAZ | Crystal structure of monoclinic form of D90E mutant of escherichia COLI asparaginase II | x-ray diffraction | A, B | — | — |
| 1JJA | Crystal structure of orthorhombic form of D90E mutant of escherichia COLI L-asparaginase II | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1JJA | Crystal structure of orthorhombic form of D90E mutant of escherichia COLI L-asparaginase II | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1NNS | L-asparaginase of E. coli in C2 space group and 1.95 A resolution | x-ray diffraction | A, B | — | — |
| 1NNS | L-asparaginase of E. COLI in C2 space group and 1.95 a resolution | x-ray diffraction | A, B | — | — |
| 4ECA | Asparaginase from E. COLI, mutant T89V with covalently bound aspartate | x-ray diffraction | A, B, C, D | — | — |
| 4ECA | Asparaginase from E. COLI, mutant T89V with covalently bound aspartate | x-ray diffraction | A, B, C, D | — | — |
| 5MQ5 | A protease-resistant N24S Escherichia coli Asparaginase mutant with outstanding stability and… | x-ray diffraction | A, C, B, D | ASP | 15 (best 0.74) |
| 5MQ5 | A protease-resistant N24S escherichia COLI asparaginase mutant with outstanding stability and… | x-ray diffraction | A, C, B, D | — | — |
| 6EOK | Crystal structure of E. coli L-asparaginase II | x-ray diffraction | A, B, C, D | ZN | 12 (best 0.87) |
| 6EOK | Crystal structure of E. COLI L-asparaginase II | x-ray diffraction | A, B, C, D | ZN | — |
| 6NX6 | ECAII(D90T,K162T) mutant in complex with citrate at pH 5 | x-ray diffraction | A, B | — | — |
| 6NX6 | ECAII(D90T,K162T) mutant in complex with citrate at pH 5 | x-ray diffraction | A, B | — | — |
| 6NX7 | ECAII(D90T,K162T) mutant in complex with citrate at pH 5.6 | x-ray diffraction | A, B | — | — |
| 6NX7 | ECAII(D90T,K162T) mutant in complex with citrate at pH 5.6 | x-ray diffraction | A, B | — | — |
| 6NX8 | ECAII(D90T,K162T) mutant in complex with citrate at pH 6.2 | x-ray diffraction | A, B | — | 4 (best 0.60) |
| 6NX8 | ECAII(D90T,K162T) mutant in complex with citrate at pH 6.2 | x-ray diffraction | A, B | — | — |
| 6NX9 | ECAII(D90T,K162T) mutant in complex with citrate at pH 7 | x-ray diffraction | A, B, C, D | — | 10 (best 0.66) |
| 6NX9 | ECAII(D90T,K162T) mutant in complex with citrate at pH 7 | x-ray diffraction | A, B, C, D | — | — |
| 6NXA | ECAII(D90T,K162T) mutant at pH 7 | x-ray diffraction | A, B, C, D | — | 10 (best 0.64) |
| 6NXA | ECAII(D90T,K162T) mutant at pH 7 | x-ray diffraction | A, B, C, D | — | — |
| 6NXB | Ecaii in complex with citrate at pH 7 | x-ray diffraction | A, B, C, D | — | 11 (best 0.64) |
| 6NXB | Ecaii in complex with citrate at pH 7 | x-ray diffraction | A, B, C, D | — | — |
| 6PA2 | E. coli L-asparaginase II mutant (K162M) in complex with L-Asp at pH 5.6 | x-ray diffraction | A, C, B, D | ASP | 7 (best 0.83) |
| 6PA2 | E. COLI L-asparaginase II mutant (K162M) in complex with L-asp at pH 5.6 | x-ray diffraction | A, C, B, D | — | — |
| 6PA3 | E. coli L-asparaginase II double mutant (T89V,K162T) in complex with L-Asn at pH 7.0 | x-ray diffraction | A, B, C, D | ASN, MG | 12 (best 0.70) |
| 6PA3 | E. COLI L-asparaginase II double mutant (T89V,K162T) in complex with L-asn at pH 7.0 | x-ray diffraction | A, B, C, D | MG | — |
| 6PA4 | E. COLI L-asparaginase II double mutant (T89V,K162T) in complex with L-asp at pH 7.0 | x-ray diffraction | A, B, C, D | — | — |
| 6PA5 | ECAII(T89V,K162T) mutant in complex with L-asn at pH 8.3 in space group P2(1) | x-ray diffraction | A, B, C, D, E, F, G, H | ASN | 20 (best 0.83) |
| 6PA5 | ECAII(T89V,K162T) mutant in complex with L-asn at pH 8.3 in space group P2(1) | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6PA6 | ECAII(T89V,K162T) MUTANT IN COMPLEX WITH L-ASN AT PH 8.3 in space group C2 | x-ray diffraction | A, B, C, D | ASN | 10 (best 0.56) |
| 6PA6 | ECAII(T89V,K162T) mutant in complex with L-asn at pH 8.3 in space group C2 | x-ray diffraction | A, B, C, D | — | — |
| 6PA8 | ECAII(T89V,K162T) mutant in complex with L-asn at pH 7.0 | x-ray diffraction | A, B, C, D | ASN, MG | 11 (best 0.66) |
| 6PA8 | ECAII(T89V,K162T) mutant in complex with L-asn at pH 7.0 | x-ray diffraction | A, B, C, D | MG | — |
| 6PA9 | E. coli L-asparaginase II mutant (T12V) in complex with L-Asn at pH 7.0 | x-ray diffraction | A, B | ASN | 4 (best 0.57) |
| 6PA9 | E. COLI L-asparaginase II mutant (T12V) in complex with L-asn at pH 7.0 | x-ray diffraction | A, B | — | — |
| 6PAA | E. coli L-asparaginase II mutant (T12V) in complex with L-Asp at pH 5.5 | x-ray diffraction | A, B, C, D | ASP | 11 (best 0.66) |
| 6PAA | E. COLI L-asparaginase II mutant (T12V) in complex with L-asp at pH 5.5 | x-ray diffraction | A, B, C, D | — | — |
| 6PAB | E. COLI L-asparaginase II in complex with L-asp at pH 7.0 | x-ray diffraction | A, B, C, D | — | — |
| 6PAC | E. coli L-asparaginase II in complex with L-Asp at pH 5.6 | x-ray diffraction | A, B, C, D | ASP | 11 (best 0.67) |
| 6PAC | E. COLI L-asparaginase II in complex with L-asp at pH 5.6 | x-ray diffraction | A, B, C, D | — | — |
| 6V23 | Ligand-free L-aspraginase II from E. coli (EcAII) | x-ray diffraction | A | — | 3 (best 0.34) |
| 6V23 | Ligand-free L-aspraginase II from E. COLI (ecaii) | x-ray diffraction | A | — | — |
| 6V24 | Complex of mutant (K162M) of E. COLI L-asparaginase II with L-asp. covalent acyl-enzyme… | x-ray diffraction | A, B, C, D | — | — |
| 6V25 | Complex of mutant (K162M) of E. coli L-asparaginase II with L-Asp | x-ray diffraction | A, C, B, D | ASP | 12 (best 0.82) |
| 6V25 | Complex of mutant (K162M) of E. COLI L-asparaginase II with L-asp | x-ray diffraction | A, C, B, D | ASP | 12 (best 0.82) |
| 6V26 | Complex of mutant (K162M) of E. coli L-asparaginase II with L-Asp | x-ray diffraction | A, B, C, D | ASP | 13 (best 0.67) |
| 6V26 | Complex of mutant (K162M) of E. COLI L-asparaginase II with L-asp | x-ray diffraction | A, B, C, D | — | — |
| 6V27 | Complex of double mutant (T89V,K162T) of E. coli L-asparaginase II with L-Asp | x-ray diffraction | A, B, C, D | — | 12 (best 0.63) |
| 6V27 | Complex of double mutant (T89V,K162T) of E. COLI L-asparaginase II with L-asp | x-ray diffraction | A, B, C, D | — | — |
| 6V28 | Complex of double mutant (T89V,K162T) of E. coli L-asparaginase II with L-Asp | x-ray diffraction | A, B, C, D | — | 12 (best 0.66) |
| 6V28 | Complex of double mutant (T89V,K162T) of E. COLI L-asparaginase II with L-asp | x-ray diffraction | A, B, C, D | — | — |
| 6V29 | Complex of double mutant (T89V,K162T) of E. COLI L-asparaginase II with L-asp | x-ray diffraction | A, B, C, D | — | — |
| 6V2A | Complex of double mutant (T89V,K162T) of E. coli L-asparaginase II with L-Asn | x-ray diffraction | A, B, C, D | ASN | 12 (best 0.68) |
| 6V2A | Complex of double mutant (T89V,K162T) of E. COLI L-asparaginase II with L-asn | x-ray diffraction | A, B, C, D | — | — |
15 records more on the page itself.
Ligands
Experiment against prediction
- 5MQ5 chain C against the predicted model P00805: TM-score 1.00, RMSD 0.20 Å
- 6V2A chain C against the predicted model P00805: TM-score 1.00, RMSD 0.22 Å
- 5MQ5 chain B against the predicted model P00805: TM-score 1.00, RMSD 0.23 Å
- 6PAA chain A against the predicted model P00805: TM-score 1.00, RMSD 0.24 Å
- 6PA6 chain C against the predicted model P00805: TM-score 1.00, RMSD 0.24 Å
- 6V24 chain C against the predicted model P00805: TM-score 1.00, RMSD 0.25 Å
- 6V2C chain B against the predicted model P00805: TM-score 1.00, RMSD 0.25 Å
- 6V2C chain B against the predicted model P00805: TM-score 1.00, RMSD 0.25 Å
- 6V2G chain D against the predicted model P00805: TM-score 1.00, RMSD 0.25 Å
- 6V2G chain D against the predicted model P00805: TM-score 1.00, RMSD 0.25 Å
Elsewhere
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