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Crystal structure of casein kinase I delta (CK1D) with alphag-in conformation

Analyse Crystal structure of casein kinase I delta (CK1D) with alphag-in conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7P7H
Type: protein
Length: 584 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Casein kinase I isoform delta
EC: 2.7.11.1, 2.7.11.26
UniProt: P48730
Ligands: AMP
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Casein kinase I isoform delta (EC 2.7.11.1, 2.7.11.26)	protein	292	39% helix, 18% strand	P48730

Ligands and binding sites

AMP · Adenosine monophosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	570	0.78	0.84	66	empty
2	242	0.59	0.80	34	AMP
3	219	0.58	0.79	30	AMP
4	228	0.55	0.78	40	empty
5	58	0.41	0.81	11	empty

Interfaces

1 interface between chains.

A–B · 663 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

7P7H · Crystal structure of Casein Kinase I delta (CK1d) with alphaG-in conformation · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48730
Elsewhere: RCSB PDB 7P7H · PDBe 7P7H · UniProt P48730

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