Research workbench
Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB5
Analyse Structure of homomeric LRRC8A volume-regulated anion channel in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7P6K
- Type
- protein
- Length
- 4,650 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Volume-regulated anion channel subunit LRRC8A; Synthetic nanobody SB5
- UniProt
- Q80WG5
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 2 distinct chains · 38% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Volume-regulated anion channel subunit LRRC8A | protein | 718 | 43% helix, 13% strand | Q80WG5 |
| I, G, H | Synthetic nanobody SB5 | protein | 114 | 3% helix, 35% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.75 | 0.98 | 27 | empty |
| 2 | 270 | 0.73 | 0.87 | 31 | empty |
| 3 | 276 | 0.73 | 0.87 | 31 | empty |
| 4 | 258 | 0.72 | 0.86 | 32 | empty |
| 5 | 880 | 0.70 | 0.75 | 97 | empty |
Interfaces
15 interfaces between chains.
- A–B · 2999 Ų buried · 22 hydrogen bonds · protein-protein
- E–F · 2985 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 2955 Ų buried · 30 hydrogen bonds · protein-protein
- A–F · 1267 Ų buried · 15 hydrogen bonds · protein-protein
- D–E · 1265 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 21 disulfide (disulfide).
Compared structures
- 7P6K · Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic… · the same entry in another collection · chain H against H, TM-score 1.00
- Q80WG5 · AlphaFold monomer V2.0 prediction for volume-regulated anion channel subunit LRRC8A… · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80WG5
- Elsewhere: RCSB PDB 7P6K · PDBe 7P6K · UniProt Q80WG5
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