Research workbench
Structure of homomeric LRRC8A volume-regulated anion channel in complex with synthetic nanobody SB3
Analyse Structure of homomeric LRRC8A volume-regulated anion channel in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7P5Y
- Type
- protein
- Length
- 5,028 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Volume-regulated anion channel subunit LRRC8A; Synthetic nanobody SB3
- UniProt
- Q80WG5
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 37% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Volume-regulated anion channel subunit LRRC8A | protein | 718 | 43% helix, 11% strand | Q80WG5 |
| G, H, I, J, K, L | Synthetic nanobody SB3 | protein | 120 | 0% helix, 45% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 975 | 0.82 | 0.83 | 99 | empty |
| 2 | 172 | 0.79 | 0.94 | 43 | empty |
| 3 | 514 | 0.74 | 0.82 | 53 | empty |
| 4 | 81 | 0.73 | 0.95 | 27 | empty |
| 5 | 412 | 0.73 | 0.84 | 38 | empty |
Interfaces
15 interfaces between chains.
- A–F · 2410 Ų buried · 21 hydrogen bonds · protein-protein
- D–E · 2366 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 2334 Ų buried · 20 hydrogen bonds · protein-protein
- E–F · 1957 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 1937 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide (disulfide).
Compared structures
- 7P5Y · Structure of homomeric LRRC8A Volume-Regulated Anion Channel in complex with synthetic… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80WG5
- Elsewhere: RCSB PDB 7P5Y · PDBe 7P5Y · UniProt Q80WG5
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